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Therapeutic strategies that target and attenuate reperfusion-induced cell death may provide novel pharmacological agents, which can be used as an adjunct to current reperfusion therapy, to limit ...

Cardiovascular Research, Review, Derek J Hausenloy, Derek M Yellon

Date : 15/02/2004 Item size : 565898 bytes

Research interest in the entity responsible for this phenomenon, the mitochondrial permeability transition pore (mPTP), has dramatically increased after demonstration that it plays a key role in the ...

Cardiovascular Research, Review, Dmitry B. Zorov, Magdalena Juhaszova, Yael Yaniv, H. Bradley Nuss, Su Wang, Steven J. Sollott

Date : 15/07/2009 Item size : 611466 bytes

Preconditioning, a series of transient intervals of ischaemia and reperfusion applied before the lethal index ischaemic event, sets in motion molecular and cellular mechanisms that increase ...

Cardiovascular Research, Review, Asger Granfeldt, David J. Lefer, Jakob Vinten-Johansen

Date : 15/07/2009 Item size : 648421 bytes

Ischemic preconditioning (IP), an endogenous protective mechanism rapidly evoked by a brief period of ischemia, is recognized for its protection in limiting myocardial necrosis, but has also shown a ...

Cardiovascular Research, Review, Zhi-Qing Zhao, Jakob Vinten-Johansen

Date : 15/08/2002 Item size : 626546 bytes

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Original Article, Derek J Hausenloy, Michael R Duchen, Derek M Yellon

Date : 01/12/2003 Item size : 267794 bytes

Abstract In the last decade, apoptosis (or programmed cell death) has become appreciated as an important process in the development of the cardiovascular system. [...]apoptosis contributes to the ...

Cardiovascular Research, Review, Waander L van Heerde, Saskia Robert-Offerman, Ewald Dumont, Leo Hofstra, Pieter A Doevendans, Jos F.M Smits, Mat J.A.P Daemen, Chris P.M Reutelingsperger

Date : 01/02/2000 Item size : 493731 bytes

[...]compensatory mechanisms included LV hypertrophy, LV chamber dilation, and enhanced and sustained activity of the sympathetic nervous system and reninangiotensin system [36]. The notion that ...

Cardiovascular Research, Review, Hani N. Sabbah

Date : 01/02/2000 Item size : 422731 bytes

Specifically, we address the role of vascular smooth muscle cell death, how this may be regulated at the molecular level and whether any of these molecular mediators will provide targets for ...

Cardiovascular Research, Review, Nicola J. McCarthy, Martin Bennett

Date : 01/02/2000 Item size : 446583 bytes

Abstract Objective: Activation of peroxisome proliferator-activated receptor α (PPARα) and PPARγ plays beneficial roles in cardiovascular disorders such as atherosclerosis and heart ...

Cardiovascular Research, Original Article, Matthieu Pesant, Stéphanie Sueur, Patrick Dutartre, Mireille Tallandier, Paul A. Grimaldi, Luc Rochette, Jean-Louis Connat

Date : 01/02/2006 Item size : 271746 bytes

In this condition, absolute or relative lack of insulin impairs cardiac glucose transport and oxidation, resulting in FA becoming the preferred means of energy supply. By gaining more insight into ...

Cardiovascular Research, Review, Thomas Pulinilkunnil, Brian Rodrigues

Date : 01/02/2006 Item size : 468991 bytes