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Abstract Objective: Puma (p53-upregulated modulator of apoptosis), a proapoptotic BH3-only member of the Bcl-2 protein family, has been implicated in the pathomechanism of several diseases, including ...

Cardiovascular Research, Original Article, Philip Nickson, Ambrus Toth, Peter Erhardt

Date : 01/01/2007 Item size : 266534 bytes

Introduction The structure and biochemical functions of cardiac mitochondria are altered during ischaemiareperfusion (IR).1,2 Impaired mitochondrial function after ischaemia are disastrous for the ...

Cardiovascular Research, ORIGINAL ARTICLES: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, Vu Thi Thu, Hyoung-Kyu Kim, Le Thanh Long, Sung-Ryul Lee, Tran My Hanh, Tae Hee Ko, Hye-Jin ...

Date : 01/05/2012 Item size : 309252 bytes

Evidence for the existence of apoptosis in the human heart has been reported in various cardiac diseases, including ischemic and non-ischemic heart failure, myocardial infarction and ...

Cardiovascular Research, Review, Giora Z. Feuerstein, Peter R. Young

Date : 01/02/2000 Item size : 352446 bytes

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an ...

Cardiovascular Research, Editorial, Derek M Yellon, James M Downey

Date : 15/08/2002 Item size : 190950 bytes

Abstract Aims The caspases are thought to be central mediators of the apoptotic program, but recent data indicate that apoptosis may also be mediated by caspase-independent mechanisms such as ...

Cardiovascular Research, Original Article, Sangita Choudhury, Soochan Bae, Sheetal R. Kumar, Qingen Ke, Bhargavi Yalamarti, Jun H. Choi, Lorrie A. Kirshenbaum, Peter M. Kang

Date : 01/01/2010 Item size : 307162 bytes

Ischemia/reperfusion-induced apoptosis: connecting nitric oxide and cell cycle regulators [...]serum stimulation of neonatal, terminally-differentiated cardiomyocytes, similarly to what happens in ...

Cardiovascular Research, Editorial, Carla Pignatti, Claudio Stefanelli

Date : 01/08/2003 Item size : 210601 bytes

[...]recent evidence indicates that the contribution of mitochondria to cell injury goes well beyond their role as death executors through the opening of mitochondrial permeability transition pore ...

Cardiovascular Research, EDITORIAL: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Derek J. Hausenloy, Marisol Ruiz-Meana

Date : 01/10/2010 Item size : 156284 bytes

Acute coronary occlusion resulting in myocardial infarction is the main mechanism by which coronary artery disease reduces survival and leads to deterioration of the quality of life, and the extent ...

Cardiovascular Research, Editorial, David Garcı́a-Dorado

Date : 15/02/2004 Item size : 147067 bytes

[...]pharmacological strategies aimed at the prevention and treatment of acute cardiovascular disease thus far mainly focus on the reduction of atherosclerotic burden (e.g. by preventative strategies ...

Cardiovascular Research, Editorial, Marcel Levi, Erik Stroes

Date : 01/06/2008 Item size : 156179 bytes

The section opens with a paper by Saraste and Pulkki [1] that reviews the current knowledge on the molecular mechanisms of apoptosis as they relate to morphologic hallmarks and their implications for ...

Cardiovascular Research, Editorial, Marcel Borgers, Liisa-Maria Voipio-Pulkki, Seigo Izumo

Date : 01/02/2000 Item size : 187734 bytes