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Abstract Objective: Proliferation of vascular smooth muscle cells (VSMC) is an important event in atherogenesis, in-stent restenosis and late vein-graft failure. Introduction Proliferation of ...

Cardiovascular Research, Original Article, Mark Bond, Graciela B. Sala-Newby, Yih-Jer Wu, Andrew C. Newby

Date : 01/01/2006 Item size : 267682 bytes

The original description Twenty-five years is a long time in biomedical research, and most of today's cardiovascular scientists were at university or high school when ischaemic preconditioning was ...

Cardiovascular Research, VIEWPOINT EDITORIAL, David Garcia-Dorado, Ignasi Barba, Javier Inserte

Date : 01/08/2011 Item size : 214564 bytes

With the initiation of ischaemia, as oxygen levels fall, ATP levels fall in the affected cells, and as minutes go by, ion pumps in the cell membranes stop. The severity of hypoxia determines whether ...

Cardiovascular Research, Editorial, Eileen M. Denovan-Wright, R. William Currie

Date : 01/11/2011 Item size : 148615 bytes

When unfolded protein accumulates secondary to a mild stress, universal protein synthesis is inhibited, but then resumes upon recovery. Nickson et al. found that UPR induced by either tunicamycin, ...

Cardiovascular Research, Editorial, Anne A. Knowlton

Date : 01/01/2007 Item size : 152198 bytes

Despite its overall beneficial effect, experimental myocardial reperfusion was associated with prominent arrhythmias, enzyme release, and other adverse phenomena that were grouped under the imprecise ...

Cardiovascular Research, Viewpoint Editorial, David Garcia-Dorado, Hans Michael Piper

Date : 01/01/2006 Item size : 186761 bytes

A second endpoint of protection on the mitochondrial level has also been described: IPC can inhibit opening of the mitochondrial transition pore (PTP) in ischemic reperfused myocardium. Inhibition ...

Cardiovascular Research, Editorial, G. Taimor

Date : 01/08/2003 Item size : 131243 bytes

Methods and results Pigs were submitted to 40 min of coronary occlusion followed by reperfusion, and received (i) no treatment, (ii) one of the following treatments: RIC (5 min ischemia/5 min ...

Cardiovascular Research, Original Article, Juan José Alburquerque-Béjar, Ignasi Barba, Javier Inserte, Elisabet Miró-Casas, Marisol Ruiz-Meana, Marcos Poncelas, Úrsula Vilardosa, Laura ...

Date : 15/07/2015 Item size : 344631 bytes

Remarkably, as the ΔΨm dissipates, i.e. under hypoxic conditions or when H+ influx follows an alternative route not coupled to energy production, mitochondria can act as ATP consumers by ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Marisol Ruiz-Meana, Celia Fernandez-Sanz, David Garcia-Dorado

Date : 01/10/2010 Item size : 637391 bytes

[...]the role of mitochondria goes beyond their capacity to create molecular fuel, to include the generation of reactive oxygen species, the regulation of calcium, and activation of cell ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON SMOOTH MUSCLE CELLS AND VASCULAR DISEASES, Emma Yu, John Mercer, Martin Bennett

Date : 15/07/2012 Item size : 535453 bytes

Importantly, starvation also decreased intracellular ATP levels and oxygen consumption leading to AMP-activated protein kinase (AMPK) activation; IGF-1 increased mitochondrial Ca2+ uptake and ...

Cardiovascular Research, Original Article, Rodrigo Troncoso, Jose Miguel Vicencio, Valentina Parra, Andriy Nemchenko, Yuki Kawashima, Andrea del Campo, Barbra Toro, Pavan K. Battiprolu, Pablo ...

Date : 01/02/2012 Item size : 398788 bytes