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Abstract Objective: The cytokine cardiotrophin-1 (CT-1) has previously been shown to protect cultured cardiocytes from cell death induced by serum removal or hypoxia when administered prior to the ...

Cardiovascular Research, Original Article, Bhawanjit K Brar, Anastasis Stephanou, Zhihong Liao, Rhona M O'Leary, Diane Pennica, Derek M Yellon, David S Latchman

Date : 01/08/2001 Item size : 297331 bytes

Therapeutic strategies that target and attenuate reperfusion-induced cell death may provide novel pharmacological agents, which can be used as an adjunct to current reperfusion therapy, to limit ...

Cardiovascular Research, Review, Derek J Hausenloy, Derek M Yellon

Date : 15/02/2004 Item size : 565898 bytes

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Original Article, Derek J Hausenloy, Michael R Duchen, Derek M Yellon

Date : 01/12/2003 Item size : 267794 bytes

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an ...

Cardiovascular Research, Editorial, Derek M Yellon, James M Downey

Date : 15/08/2002 Item size : 190950 bytes

Abstract Background: Recent studies have postulated that mitochondrial ATP-sensitive potassium (mitoKATP) channel activation may modulate mitochondrial function with the resultant induction of a ...

Cardiovascular Research, Original Article, Jan Minners, Ewout J van den Bos, Derek M Yellon, Herzl Schwalb, Lionel H Opie, Michael N Sack

Date : 01/07/2000