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Ehjcardiovascrec

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes
Ehjcardiovascrec

The research article which attracted our attention was by two pioneers in MPTP research, Fabio Di Lisa and Paulo Bernardi at the University of Padova.1 In their experimental study, they had ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Derek J. Hausenloy, Helen L. Maddock, Gary F. Baxter, Derek M. Yellon

Date : 01/11/2012 Item size : 280986 bytes
Ehjcardiovascrec

Abstract Aims In the heart, a period of ischaemia followed by reperfusion evokes powerful cytosolic Ca2+ oscillations that can cause lethal cell injury. Restoration of blood supply is essential to ...

Cardiovascular Research, Cardiac biology and remodelling, Sean M. Davidson, Kirsty Foote, Suma Kunuthur, Raj Gosain, Noah Tan, Richard Tyser, Yong Juan Zhao, Richard Graeff, A. Ganesan, Michael R. ...

Date : 01/12/2015
Ehjcardiovascrec

Results: CT-1 has a protective effect in reducing ischaemic damage in the intact heart ex vivo as assayed by infarct size to area at risk ratio (20% compared to 35%). Both in vitro and ex vivo CT-1 ...

Cardiovascular Research, Original Article, Zhihong Liao, Bhawanjit K. Brar, Qing Cai, Anastasis Stephanou, Rhona M. O'Leary, Diane Pennica, Derek M. Yellon, David S. Latchman

Date : 01/03/2002
Ehjcardiovascrec

Abstract Aims Opening of the mitochondrial permeability transition pore (mPTP) is an important step on the pathway towards cardiomyocyte death, defining the extent of injury following cardiac ...

Cardiovascular Research, Original Article, Sean M. Davidson, Derek M. Yellon, Michael P. Murphy, Michael R. Duchen

Date : 01/03/2012
Ehjcardiovascrec

The mechanisms of protection by postconditioning include: formation and release of several autacoids and cytokines; maintained acidosis during early reperfusion; activation of protein kinases; ...

Cardiovascular Research, Review, Michel Ovize, Gary F. Baxter, Fabio Di Lisa, Péter Ferdinandy, David Garcia-Dorado, Derek J. Hausenloy, Gerd Heusch, Jakob Vinten-Johansen, Derek M. Yellon, Rainer ...

Date : 01/08/2010
Ehjcardiovascrec

KeywordsIschemiaMitochondriaReperfusionPreconditioningTime for primary review 18 days 1 Introduction Ischemic preconditioning (IPC), first described by Murry and co-workers in 1986 [1] as an ...

Cardiovascular Research, Original Article, Shiang Y. Lim, Sean M. Davidson, Derek J. Hausenloy, Derek M. Yellon

Date : 01/08/2007
Ehjcardiovascrec

During reperfusion, calcium overloading, elevated levels of reactive oxygen species (ROS), and abrupt restoration of pH, all act in concert to induce mitochondrial dysfunction leading to the ...

Cardiovascular Research, Cardiac biology and remodelling, Sang-Ging Ong, Won Hee Lee, Louise Theodorou, Kazuki Kodo, Shiang Y. Lim, Deepa H. Shukla, Thomas Briston, Serafim Kiriakidis, Margaret ...

Date : 01/10/2014