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Abstract Gap junction-mediated intercellular communication (GJMIC) has been known for a long time to be essential in propagation of electrical impulse in the heart, and the contribution of altered ...

Cardiovascular Research, Garcı́a-Dorado, David, Rodrı́guez-Sinovas, Antonio, Ruiz-Meana, Marisol

Date : 15/02/2004 Item size : 576029 bytes

Remarkably, as the ΔΨm dissipates, i.e. under hypoxic conditions or when H+ influx follows an alternative route not coupled to energy production, mitochondria can act as ATP consumers by ...

Cardiovascular Research, Ruiz-Meana, Marisol, Fernandez-Sanz, Celia, Garcia-Dorado, David

Date : 01/10/2010 Item size : 610748 bytes

Since its first description 25 years ago,1 ischaemic preconditioning has become one of the most studied protective interventions in the cardiovascular field, in part due to its universality (it is ...

Cardiovascular Research, Ruiz-Meana, Marisol

Date : 01/11/2012 Item size : 186987 bytes

Methods: Calpain activity and degradation of different structural proteins were studied along with the extent of necrosis in isolated rat hearts submitted to 60 min of ischemia and 30 min of ...

Cardiovascular Research, Inserte, Javier, Garcia-Dorado, David, Ruiz-Meana, Marisol, Agulló, Luis, Pina, Pilar, Soler-Soler, Jordi

Date : 01/10/2004 Item size : 295461 bytes

[...]the so-called Ca2+ paradox (hypercontracture and death of cardiomyocytes occurring upon restoration of Ca2+ after a Ca2+-free perfusion period) was meant to be a first cellular model of ...

Cardiovascular Research, Garcia-Dorado, David, Ruiz-Meana, Marisol, Inserte, Javier, Rodriguez-Sinovas, Antonio, Piper, Hans Michael

Date : 01/05/2012 Item size : 742256 bytes

In myocardium, gap junction communication is altered during ischemia, which contributes to the development of arrhythmias, but still allows synchronization of the onset of rigor contracture in the ...

Cardiovascular Research, Garcia-Dorado, David, Ruiz-Meana, Marisol, Padilla, Ferran, Rodriguez-Sinovas, Antonio, Mirabet, Maribel

Date : 15/08/2002 Item size : 556417 bytes

[...]in animals, interventions against lethal reperfusion injury are usually tested in the absence of other medications, in contrast to what happens in patients with acute coronary syndrome. Recent ...

Cardiovascular Research, Garcia-Dorado, David, Ruiz-Meana, Marisol, Piper, Hans Michael

Date : 15/07/2009 Item size : 184564 bytes

Methods and results The effect of acidic perfusion on reperfusion injury was studied in isolated rat hearts submitted to 40 min of ischaemia and 30 min of reperfusion, and its effect on the ...

Cardiovascular Research, Inserte, Javier, Barba, Ignasi, Hernando, Víctor, Abellán, Arancha, Ruiz-Meana, Marisol, Rodríguez-Sinovas, Antonio, Garcia-Dorado, David

Date : 01/03/2008 Item size : 272503 bytes

In the present article, the role of proposed end-effectors of preconditioning protection, defined as molecules directly involved in cell death that are modified by ischemic preconditioning (IP), is ...

Cardiovascular Research, Garcia-Dorado, David, Rodriguez-Sinovas, Antonio, Ruiz-Meana, Marisol, Inserte, Javier, Agulló, Luis, Cabestrero, Alberto

Date : 01/05/2006 Item size : 545409 bytes

Methods: The effect of several concentrations of KB-R7943 added at reperfusion was studied in Fura-2 loaded quiescent cardiomyocytes submitted to 40 min of simulated ischemia (NaCN 2 mM, pH 6.4), and ...

Cardiovascular Research, Inserte, Javier, Garcia-Dorado, David, Ruiz-Meana, Marisol, Padilla, Ferran, Barrabés, José A, Pina, Pilar, Agulló, Luis, Piper, Hans Michael, Soler-Soler, Jordi

Date : 01/09/2002 Item size : 287240 bytes