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Abstract Macrophages play a key role in atherosclerotic plaque destabilization and rupture. [...]macrophages are phagocytic cells and thus have an important additional role in scavenging of modified ...

Cardiovascular Research, Review, Dorien M. Schrijvers, Guido R.Y. De Meyer, Arnold G. Herman, Wim Martinet

Date : 01/02/2007 Item size : 443225 bytes

Endothelial cell biology and pathology Once viewed as a passive inner cover of the vessel wall, the endothelium is now recognized as an active organ with many important functions, such as regulation ...

Cardiovascular Research, Review, Gian Paolo Fadini, Angelo Avogaro

Date : 01/07/2010 Item size : 471363 bytes

Ang II increased ERK phosphorylation, which was inhibited by addition of the AT1 receptor-specific antagonist CV11974, but enhanced by addition of the AT2 receptor-specific antagonist PD123319, ...

Cardiovascular Research, Original Article, Tai-Xing Cui, Hironori Nakagami, Masaru Iwai, Yuko Takeda, Tetsuya Shiuchi, Laurent Daviet, Clara Nahmias, Masatsugu Horiuchi

Date : 01/03/2001 Item size : 291255 bytes

Abstract Aims The aim of this study was to take a combination of animal and cell culture approaches to examine the individual responses of vascular cells to varying inflammatory factors in order to ...

Cardiovascular Research, Original Article, Chetan P. Hans, Mourad Zerfaoui, Amarjit S. Naura, Andrew Catling, A. Hamid Boulares

Date : 01/06/2008 Item size : 230010 bytes

[...]pharmacological strategies aimed at the prevention and treatment of acute cardiovascular disease thus far mainly focus on the reduction of atherosclerotic burden (e.g. by preventative strategies ...

Cardiovascular Research, Editorial, Marcel Levi, Erik Stroes

Date : 01/06/2008 Item size : 156179 bytes

Abstract Objectives Septic shock and sequential multiple organ failure remain the cause of death in septic patients. Synthetic small interfering RNAs (siRNAs) specifically suppress gene expression ...

Cardiovascular Research, Original Article, Naoyuki Matsuda, Yasuo Takano, Shun-ichiro Kageyama, Noboru Hatakeyama, Kiyoshi Shakunaga, Isao Kitajima, Mitsuaki Yamazaki, Yuichi Hattori

Date : 01/10/2007 Item size : 307264 bytes

Lipopolysaccharide (LPS)-induced reactive oxygen species (ROS)-mediated endothelial cell death is a main feature observed in inflammation secondary to endotoxaemia, emerging as a leading cause of ...

Cardiovascular Research, Original Article, Alvaro Becerra, Cesar Echeverría, Diego Varela, Daniela Sarmiento, Ricardo Armisén, Felipe Nuñez-Villena, Mario Montecinos, Felipe Simon

Date : 01/09/2011 Item size : 314461 bytes

Abstract Although the specific roles of nitric oxide (NO) in the heart in general and on cardiac mitochondria in particular remain controversial, it is now clear that both endogenous and exogenous ...

Cardiovascular Research, Review, Sean M. Davidson, Michael R. Duchen

Date : 01/07/2006 Item size : 551284 bytes

[...]collagen deposition is increased and tissue repair is enhanced with myocardial fibrosis and angiogenesis. Since the extent of LV remodelling is a major predictor of prognosis of the patients ...

Cardiovascular Research, Review, Masatsugu Hori, Kazuhiko Nishida

Date : 15/02/2009 Item size : 526580 bytes

Caspase-dependent signalling is important during heart morphogenesis and is later silenced in post-mitotic cardiomyocytes Cell death implying apoptotic-like DNA damage occurs during embryonic heart ...

Cardiovascular Research, VIEWPOINT EDITORIAL, Daniel Sanchis, Marta Llovera, Manel Ballester, Joan X. Comella

Date : 01/02/2008