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Ehjcardiovascrec

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes
Ehjcardiovascrec

[...]compensatory mechanisms included LV hypertrophy, LV chamber dilation, and enhanced and sustained activity of the sympathetic nervous system and reninangiotensin system [36]. The notion that ...

Cardiovascular Research, Review, Hani N. Sabbah

Date : 01/02/2000 Item size : 422731 bytes
Ehjcardiovascrec

Programmed cell death (apoptosis) of cardiac muscle cells has been identified as an essential process in the progression to heart failure. [...]the present review summarizes the apoptotic pathways ...

Cardiovascular Research, Review, Vanessa P.M. van Empel, Anne T.A. Bertrand, Leo Hofstra, Harry J. Crijns, Pieter A. Doevendans, Leon J. De Windt

Date : 01/07/2005 Item size : 392260 bytes
Ehjcardiovascrec

Abstract Cardiomyocytes are terminally differentiated cells and thus do not have the ability to dilute damaged proteins and organelles by cell division. [...]proteolytic and recycling systems within ...

Cardiovascular Research, REVIEWS: FOCUS ON THE CALPAIN FAMILY IN THE CARDIOVASCULAR SYSTEM, Osamu Yamaguchi, Manabu Taneike, Kinya Otsu

Date : 01/10/2012 Item size : 446563 bytes
Ehjcardiovascrec

Owing to their dependence on Ca2+, calpains have attracted much attention as modulators implicated in a wide variety of biological phenomena including proliferation, cell migration, differentiation, ...

Cardiovascular Research, Editorial, Javier Inserte

Date : 01/10/2012 Item size : 179731 bytes
Ehjcardiovascrec

The concept of cardiac remodelling was initially created to describe the changes in the anatomy of the left ventricle that occur following myocardial infarction.1 Today myocardial remodelling is used ...

Cardiovascular Research, Editorial, Javier Díez, Georg Ertl

Date : 15/02/2009 Item size : 201037 bytes
Ehjcardiovascrec

Abstract Objective: Puma (p53-upregulated modulator of apoptosis), a proapoptotic BH3-only member of the Bcl-2 protein family, has been implicated in the pathomechanism of several diseases, including ...

Cardiovascular Research, Original Article, Philip Nickson, Ambrus Toth, Peter Erhardt

Date : 01/01/2007 Item size : 266534 bytes
Ehjcardiovascrec

Evidence for the existence of apoptosis in the human heart has been reported in various cardiac diseases, including ischemic and non-ischemic heart failure, myocardial infarction and ...

Cardiovascular Research, Review, Giora Z. Feuerstein, Peter R. Young

Date : 01/02/2000 Item size : 352446 bytes
Ehjcardiovascrec

Abstract Aims The caspases are thought to be central mediators of the apoptotic program, but recent data indicate that apoptosis may also be mediated by caspase-independent mechanisms such as ...

Cardiovascular Research, Original Article, Sangita Choudhury, Soochan Bae, Sheetal R. Kumar, Qingen Ke, Bhargavi Yalamarti, Jun H. Choi, Lorrie A. Kirshenbaum, Peter M. Kang

Date : 01/01/2010 Item size : 307162 bytes
Ehjcardiovascrec

In response to diverse load conditions (pressure, volume, etc.), heart muscle cells typically hypertrophy or commit suicide in a process commonly referred to as left ventricular remodeling. A ...

Cardiovascular Research, Review, Vanessa P.M van Empel, Leon J De Windt

Date : 15/08/2004 Item size : 577759 bytes