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Methods Intracellular Na+ concentration ([Na+]i) measured using 23Na-magnetic resonance spectroscopy, Na+/K+-ATPase activity, detachment of Na+/K+-ATPase α subunits from the membrane cytoskeleton, ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Victor Hernando, Ignasi Barba, Jordi Soler-Soler

Date : 01/05/2006 Item size : 287033 bytes

Abstract This brief review summarizes the recently obtained evidence which illustrates the beneficial effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage and ...

Cardiovascular Research, Review, Russel J. Reiter, Dun-Xian Tan

Date : 01/04/2003 Item size : 397783 bytes

Preconditioning, a series of transient intervals of ischaemia and reperfusion applied before the lethal index ischaemic event, sets in motion molecular and cellular mechanisms that increase ...

Cardiovascular Research, Review, Asger Granfeldt, David J. Lefer, Jakob Vinten-Johansen

Date : 15/07/2009 Item size : 648421 bytes

Ischemic preconditioning (IP), an endogenous protective mechanism rapidly evoked by a brief period of ischemia, is recognized for its protection in limiting myocardial necrosis, but has also shown a ...

Cardiovascular Research, Review, Zhi-Qing Zhao, Jakob Vinten-Johansen

Date : 15/08/2002 Item size : 626546 bytes

The original description Twenty-five years is a long time in biomedical research, and most of today's cardiovascular scientists were at university or high school when ischaemic preconditioning was ...

Cardiovascular Research, VIEWPOINT EDITORIAL, David Garcia-Dorado, Ignasi Barba, Javier Inserte

Date : 01/08/2011 Item size : 214564 bytes

Methods and results Pigs were submitted to 40 min of coronary occlusion followed by reperfusion, and received (i) no treatment, (ii) one of the following treatments: RIC (5 min ischemia/5 min ...

Cardiovascular Research, Original Article, Juan José Alburquerque-Béjar, Ignasi Barba, Javier Inserte, Elisabet Miró-Casas, Marisol Ruiz-Meana, Marcos Poncelas, Úrsula Vilardosa, Laura ...

Date : 15/07/2015 Item size : 344631 bytes

KeywordsBlood flowCollateral circulationCoronary circulationCoronary diseaseInfarctionIschemia 1 Introduction There are several villains in this story: (i) researchers who convinced themselves that ...

Cardiovascular Research, Historical note, David J Hearse

Date : 01/01/2000

Abstract Background: Recent studies have postulated that mitochondrial ATP-sensitive potassium (mitoKATP) channel activation may modulate mitochondrial function with the resultant induction of a ...

Cardiovascular Research, Original Article, Jan Minners, Ewout J van den Bos, Derek M Yellon, Herzl Schwalb, Lionel H Opie, Michael N Sack

Date : 01/07/2000

Abstract Aims Transient receptor potential melastatin 2 (TRPM2) highly expressed in immunocytes is a Ca2+-permeable non-selective cation channel activated by oxidative stress. Transient receptor ...

Cardiovascular Research, Cardiac biology and remodelling, Toshihito Hiroi, Teruaki Wajima, Takaharu Negoro, Masakazu Ishii, Yasuko Nakano, Yuji Kiuchi, Yasuo Mori, Shunichi Shimizu

Date : 01/02/2013

[...]recent studies indicate that there are important non-transcriptional effects of p53 on apoptosis that involve its ability to suppress anti-apoptotic or activate pro-apoptotic Bcl-2 family ...

Cardiovascular Research, Editorial, Michael T. Crow

Date : 01/06/2006