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Methods Intracellular Na+ concentration ([Na+]i) measured using 23Na-magnetic resonance spectroscopy, Na+/K+-ATPase activity, detachment of Na+/K+-ATPase α subunits from the membrane cytoskeleton, ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Victor Hernando, Ignasi Barba, Jordi Soler-Soler

Date : 01/05/2006 Item size : 287033 bytes

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes

Ischemic preconditioning (IP), an endogenous protective mechanism rapidly evoked by a brief period of ischemia, is recognized for its protection in limiting myocardial necrosis, but has also shown a ...

Cardiovascular Research, Review, Zhi-Qing Zhao, Jakob Vinten-Johansen

Date : 15/08/2002 Item size : 626546 bytes

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an ...

Cardiovascular Research, Editorial, Derek M Yellon, James M Downey

Date : 15/08/2002 Item size : 190950 bytes

Despite its overall beneficial effect, experimental myocardial reperfusion was associated with prominent arrhythmias, enzyme release, and other adverse phenomena that were grouped under the imprecise ...

Cardiovascular Research, Viewpoint Editorial, David Garcia-Dorado, Hans Michael Piper

Date : 01/01/2006 Item size : 186761 bytes

In myocardium, gap junction communication is altered during ischemia, which contributes to the development of arrhythmias, but still allows synchronization of the onset of rigor contracture in the ...

Cardiovascular Research, Review, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, Antonio Rodriguez-Sinovas, Maribel Mirabet

Date : 15/08/2002 Item size : 519924 bytes

Abstract The aged heart has a diminished functional and adaptive reserve capacity, an increased susceptibility to incur damage (e.g., as a result of ischemia), and a limited practical ability for ...

Cardiovascular Research, Review, Magdalena Juhaszova, Christophe Rabuel, Dmitry B. Zorov, Edward G. Lakatta, Steven J. Sollott

Date : 01/05/2005 Item size : 569776 bytes

Abstract Background: Recent studies have postulated that mitochondrial ATP-sensitive potassium (mitoKATP) channel activation may modulate mitochondrial function with the resultant induction of a ...

Cardiovascular Research, Original Article, Jan Minners, Ewout J van den Bos, Derek M Yellon, Herzl Schwalb, Lionel H Opie, Michael N Sack

Date : 01/07/2000

In this study, we examined the ability of IP to attenuate processing and activation of caspase-1 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP), after prolonged ischemia and ...

Cardiovascular Research, Original Article, Christophe A Piot, Jean-François Martini, Steve K Bui, Christopher L Wolfe

Date : 01/12/1999

Methods: Calpain activity and degradation of different structural proteins were studied along with the extent of necrosis in isolated rat hearts submitted to 60 min of ischemia and 30 min of ...

Cardiovascular Research, Research Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Luis Agulló, Pilar Pina, Jordi Soler-Soler

Date : 01/10/2004