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Methods: The effect of several concentrations of KB-R7943 added at reperfusion was studied in Fura-2 loaded quiescent cardiomyocytes submitted to 40 min of simulated ischemia (NaCN 2 mM, pH 6.4), and ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, José A Barrabés, Pilar Pina, Luis Agulló, Hans Michael Piper, Jordi ...

Date : 01/09/2002 Item size : 271773 bytes

Therapeutic strategies that target and attenuate reperfusion-induced cell death may provide novel pharmacological agents, which can be used as an adjunct to current reperfusion therapy, to limit ...

Cardiovascular Research, Review, Derek J Hausenloy, Derek M Yellon

Date : 15/02/2004 Item size : 565898 bytes

Introduction Since the protection afforded by brief episodes of ischemia against cell death induced by subsequent prolonged ischemia and reperfusion was originally described in 1986 [1], an enormous ...

Cardiovascular Research, Review, David Garcia-Dorado, Antonio Rodriguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, Luis Agulló, Alberto Cabestrero

Date : 01/05/2006 Item size : 490461 bytes

The identification of the mechanisms of reperfusion-induced cell death opens a new window of opportunity for cardioprotection in the clinic. On the cellular level, it was shown that ...

Cardiovascular Research, Review, H.M Piper, Y Abdallah, C Schäfer

Date : 15/02/2004 Item size : 238908 bytes

Acute coronary occlusion resulting in myocardial infarction is the main mechanism by which coronary artery disease reduces survival and leads to deterioration of the quality of life, and the extent ...

Cardiovascular Research, Editorial, David Garcı́a-Dorado

Date : 15/02/2004 Item size : 147067 bytes

Despite its overall beneficial effect, experimental myocardial reperfusion was associated with prominent arrhythmias, enzyme release, and other adverse phenomena that were grouped under the imprecise ...

Cardiovascular Research, Viewpoint Editorial, David Garcia-Dorado, Hans Michael Piper

Date : 01/01/2006 Item size : 186761 bytes

Introduction In patients with ST-segment elevation acute myocardial infarction (AMI), the main therapeutic goal is to restore coronary flow as soon as possible by means of percutaneous intervention ...

Cardiovascular Research, Review, Javier Inserte, José A. Barrabés, Víctor Hernando, David Garcia-Dorado

Date : 15/07/2009 Item size : 489326 bytes

Following his landmark description of the postconditioning phenomenon, Vinten-Johansen's group completed a second study which clearly identified one major limitation of this protection against lethal ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Michel Ovize

Date : 01/11/2012 Item size : 156977 bytes

KeywordsIschemiaReperfusionMitochondriaThe development of thrombolysis and coronary angioplasty has clearly improved the prognosis of patients with acute myocardial infarction (AMI). Despite these ...

Cardiovascular Research, Review, Odile Gateau-Roesch, Laurent Argaud, Michel Ovize

Date : 01/05/2006 Item size : 378602 bytes

The combination of faster access to reperfusion therapy, thromboaspiration, prevention of embolization and stenting, and optimized antiplatelet therapy to prevent acute thrombotic reocclusion have ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, Olivier Morel, Thibault Perret, Nicolas Delarche, Jean-Noel Labèque, Bernard Jouve, Meier Elbaz, ...

Date : 01/05/2012