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Methods and results We used several types of cultured mouse, rat, and bovine cells from the cardiovascular system, and evaluated mitochondrial morphology, reactive oxygen species (ROS) levels, and ...

Cardiovascular Research, Original Article, Tianzheng Yu, Shey-Shing Sheu, James L. Robotham, Yisang Yoon

Date : 15/07/2008 Item size : 328023 bytes

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

Research interest in the entity responsible for this phenomenon, the mitochondrial permeability transition pore (mPTP), has dramatically increased after demonstration that it plays a key role in the ...

Cardiovascular Research, Review, Dmitry B. Zorov, Magdalena Juhaszova, Yael Yaniv, H. Bradley Nuss, Su Wang, Steven J. Sollott

Date : 15/07/2009 Item size : 611466 bytes

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Original Article, Derek J Hausenloy, Michael R Duchen, Derek M Yellon

Date : 01/12/2003 Item size : 267794 bytes

Whether cardiac mitochondria have an innate capacity to temporally self-modulate their membrane potential as a possible adaptive mechanism in the context of cardiac ischemia and early reperfusion is ...

Cardiovascular Research, Review, Michael N. Sack

Date : 01/11/2006 Item size : 474381 bytes

The 1990s saw a huge resurgence of interest in the role of mitochondria within cells, recognition that, as well as their traditional role as powerhouses of the cell in generating ATP, mitochondria ...

Cardiovascular Research, Editorial, Elinor J. Griffiths

Date : 01/04/2000 Item size : 199134 bytes

Introduction The structure and biochemical functions of cardiac mitochondria are altered during ischaemiareperfusion (IR).1,2 Impaired mitochondrial function after ischaemia are disastrous for the ...

Cardiovascular Research, ORIGINAL ARTICLES: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, Vu Thi Thu, Hyoung-Kyu Kim, Le Thanh Long, Sung-Ryul Lee, Tran My Hanh, Tae Hee Ko, Hye-Jin ...

Date : 01/05/2012 Item size : 309252 bytes

[...]the role of mitochondria goes beyond their capacity to create molecular fuel, to include the generation of reactive oxygen species, the regulation of calcium, and activation of cell ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON SMOOTH MUSCLE CELLS AND VASCULAR DISEASES, Emma Yu, John Mercer, Martin Bennett

Date : 15/07/2012 Item size : 535453 bytes

[...]the role of the mitochondrial uncoupling proteins in ischaemia tolerance is discussed. Mitochondria are essential organelles in any tissue, but when oxygen availability is limited they can ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Susana Cadenas, Julián Aragonés, Manuel O. Landázuri

Date : 01/11/2010 Item size : 633400 bytes

According to the classical view, necrosis is the major mechanism of cardiomyocyte death in cardiac diseases. [...]the perspectives of strategies aimed to detect and modulate apoptosis of ...

Cardiovascular Research, Review, Arantxa González, Marı́a A Fortuño, Ramón Querejeta, Susana Ravassa, Begoña López, Natalia López, Javier Dı́ez

Date : 01/09/2003 Item size : 671254 bytes