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Methods and results We used several types of cultured mouse, rat, and bovine cells from the cardiovascular system, and evaluated mitochondrial morphology, reactive oxygen species (ROS) levels, and ...

Cardiovascular Research, Original Article, Tianzheng Yu, Shey-Shing Sheu, James L. Robotham, Yisang Yoon

Date : 15/07/2008 Item size : 328023 bytes

Methods Intracellular Na+ concentration ([Na+]i) measured using 23Na-magnetic resonance spectroscopy, Na+/K+-ATPase activity, detachment of Na+/K+-ATPase α subunits from the membrane cytoskeleton, ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Victor Hernando, Ignasi Barba, Jordi Soler-Soler

Date : 01/05/2006 Item size : 287033 bytes

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

Research interest in the entity responsible for this phenomenon, the mitochondrial permeability transition pore (mPTP), has dramatically increased after demonstration that it plays a key role in the ...

Cardiovascular Research, Review, Dmitry B. Zorov, Magdalena Juhaszova, Yael Yaniv, H. Bradley Nuss, Su Wang, Steven J. Sollott

Date : 15/07/2009 Item size : 611466 bytes

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Original Article, Derek J Hausenloy, Michael R Duchen, Derek M Yellon

Date : 01/12/2003 Item size : 267794 bytes

Introduction Since the protection afforded by brief episodes of ischemia against cell death induced by subsequent prolonged ischemia and reperfusion was originally described in 1986 [1], an enormous ...

Cardiovascular Research, Review, David Garcia-Dorado, Antonio Rodriguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, Luis Agulló, Alberto Cabestrero

Date : 01/05/2006 Item size : 490461 bytes

Abstract Objective: Diminishing oxidative stress may protect the heart against ischaemiareperfusion injury by preventing opening of the mitochondrial permeability transition (MPT) pore. The ...

Cardiovascular Research, Original Article, Sabzali A. Javadov, Kelvin H.H. Lim, Paul M. Kerr, M.-Saadah Suleiman, Gianni D. Angelini, Andrew P. Halestrap

Date : 14/01/2000 Item size : 327545 bytes

Programmed cell death (apoptosis) of cardiac muscle cells has been identified as an essential process in the progression to heart failure. [...]the present review summarizes the apoptotic pathways ...

Cardiovascular Research, Review, Vanessa P.M. van Empel, Anne T.A. Bertrand, Leo Hofstra, Harry J. Crijns, Pieter A. Doevendans, Leon J. De Windt

Date : 01/07/2005 Item size : 392260 bytes

The 1990s saw a huge resurgence of interest in the role of mitochondria within cells, recognition that, as well as their traditional role as powerhouses of the cell in generating ATP, mitochondria ...

Cardiovascular Research, Editorial, Elinor J. Griffiths

Date : 01/04/2000 Item size : 199134 bytes