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Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Original Article, Derek J Hausenloy, Michael R Duchen, Derek M Yellon

Date : 01/12/2003 Item size : 267794 bytes

Abstract Objective: Activation of peroxisome proliferator-activated receptor α (PPARα) and PPARγ plays beneficial roles in cardiovascular disorders such as atherosclerosis and heart ...

Cardiovascular Research, Original Article, Matthieu Pesant, Stéphanie Sueur, Patrick Dutartre, Mireille Tallandier, Paul A. Grimaldi, Luc Rochette, Jean-Louis Connat

Date : 01/02/2006 Item size : 271746 bytes

Abstract Objective: Diminishing oxidative stress may protect the heart against ischaemiareperfusion injury by preventing opening of the mitochondrial permeability transition (MPT) pore. The ...

Cardiovascular Research, Original Article, Sabzali A. Javadov, Kelvin H.H. Lim, Paul M. Kerr, M.-Saadah Suleiman, Gianni D. Angelini, Andrew P. Halestrap

Date : 14/01/2000 Item size : 327545 bytes

The concept of cardiac remodelling was initially created to describe the changes in the anatomy of the left ventricle that occur following myocardial infarction.1 Today myocardial remodelling is used ...

Cardiovascular Research, Editorial, Javier Díez, Georg Ertl

Date : 15/02/2009 Item size : 201037 bytes

Dysfunction and β-cell death normally follows an immune attack.1,2 As a result, there is decreased insulin synthesis and secretion.1 Compared to T1D, Type 2 diabetes (T2D) is the major form of ...

Cardiovascular Research, TOPICAL REVIEWS, Prasanth Puthanveetil, Andrea Wan, Brian Rodrigues

Date : 01/03/2013 Item size : 582544 bytes

Abstract Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore ...

Cardiovascular Research, Review, Andrew P Halestrap, Samantha J Clarke, Sabzali A Javadov

Date : 15/02/2004 Item size : 445160 bytes

ROS and cellular redox conditions regulate a large number of vital pathways (energy metabolism, survival/stress responses, apoptosis, inflammatory response, oxygen sensing, etc). While cellular ...

Cardiovascular Research, Review, Lance B Becker

Date : 15/02/2004 Item size : 327763 bytes

[...]we discuss therapeutic strategies that prevent arrhythmias by preserving mitochondrial membrane potential in the face of oxidative stress, supporting the notion that treatments aimed at cardiac ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, David A. Brown, Brian O'Rourke

Date : 01/11/2010 Item size : 639011 bytes

Abstract Aims The aim of this study was to take a combination of animal and cell culture approaches to examine the individual responses of vascular cells to varying inflammatory factors in order to ...

Cardiovascular Research, Original Article, Chetan P. Hans, Mourad Zerfaoui, Amarjit S. Naura, Andrew Catling, A. Hamid Boulares

Date : 01/06/2008 Item size : 230010 bytes