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Ehjcardiovascrec

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes
Ehjcardiovascrec

Research interest in the entity responsible for this phenomenon, the mitochondrial permeability transition pore (mPTP), has dramatically increased after demonstration that it plays a key role in the ...

Cardiovascular Research, Review, Dmitry B. Zorov, Magdalena Juhaszova, Yael Yaniv, H. Bradley Nuss, Su Wang, Steven J. Sollott

Date : 15/07/2009 Item size : 611466 bytes
Ehjcardiovascrec

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Original Article, Derek J Hausenloy, Michael R Duchen, Derek M Yellon

Date : 01/12/2003 Item size : 267794 bytes
Ehjcardiovascrec

Introduction Since the protection afforded by brief episodes of ischemia against cell death induced by subsequent prolonged ischemia and reperfusion was originally described in 1986 [1], an enormous ...

Cardiovascular Research, Review, David Garcia-Dorado, Antonio Rodriguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, Luis Agulló, Alberto Cabestrero

Date : 01/05/2006 Item size : 490461 bytes
Ehjcardiovascrec

Programmed cell death (apoptosis) of cardiac muscle cells has been identified as an essential process in the progression to heart failure. [...]the present review summarizes the apoptotic pathways ...

Cardiovascular Research, Review, Vanessa P.M. van Empel, Anne T.A. Bertrand, Leo Hofstra, Harry J. Crijns, Pieter A. Doevendans, Leon J. De Windt

Date : 01/07/2005 Item size : 392260 bytes
Ehjcardiovascrec

Abstract Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore ...

Cardiovascular Research, Review, Andrew P Halestrap, Samantha J Clarke, Sabzali A Javadov

Date : 15/02/2004 Item size : 445160 bytes
Ehjcardiovascrec

Acute coronary occlusion resulting in myocardial infarction is the main mechanism by which coronary artery disease reduces survival and leads to deterioration of the quality of life, and the extent ...

Cardiovascular Research, Editorial, David Garcı́a-Dorado

Date : 15/02/2004 Item size : 147067 bytes
Ehjcardiovascrec

Introduction In patients with ST-segment elevation acute myocardial infarction (AMI), the main therapeutic goal is to restore coronary flow as soon as possible by means of percutaneous intervention ...

Cardiovascular Research, Review, Javier Inserte, José A. Barrabés, Víctor Hernando, David Garcia-Dorado

Date : 15/07/2009 Item size : 489326 bytes
Ehjcardiovascrec

Following his landmark description of the postconditioning phenomenon, Vinten-Johansen's group completed a second study which clearly identified one major limitation of this protection against lethal ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Michel Ovize

Date : 01/11/2012 Item size : 156977 bytes
Ehjcardiovascrec

KeywordsIschemiaReperfusionMitochondriaThe development of thrombolysis and coronary angioplasty has clearly improved the prognosis of patients with acute myocardial infarction (AMI). Despite these ...

Cardiovascular Research, Review, Odile Gateau-Roesch, Laurent Argaud, Michel Ovize

Date : 01/05/2006 Item size : 378602 bytes