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Abstract Aims It has been shown that sarcoplasmic reticulum calcium ATPase (SERCA) plays a critical role in reperfusion injury. [...]ischaemic post-conditioning (PoCo) results in protein kinase G ...

Cardiovascular Research, Cardiac biology and remodelling, Javier Inserte, Víctor Hernando, Marisol Ruiz-Meana, Marcos Poncelas-Nozal, Celia Fernández, Luis Agulló, Carmem Sartorio, Úrsula ...

Date : 01/09/2014 Item size : 366352 bytes

Abstract Objective: Puma (p53-upregulated modulator of apoptosis), a proapoptotic BH3-only member of the Bcl-2 protein family, has been implicated in the pathomechanism of several diseases, including ...

Cardiovascular Research, Original Article, Philip Nickson, Ambrus Toth, Peter Erhardt

Date : 01/01/2007 Item size : 266534 bytes

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an ...

Cardiovascular Research, Editorial, Derek M Yellon, James M Downey

Date : 15/08/2002 Item size : 190950 bytes

Importantly, starvation also decreased intracellular ATP levels and oxygen consumption leading to AMP-activated protein kinase (AMPK) activation; IGF-1 increased mitochondrial Ca2+ uptake and ...

Cardiovascular Research, Original Article, Rodrigo Troncoso, Jose Miguel Vicencio, Valentina Parra, Andriy Nemchenko, Yuki Kawashima, Andrea del Campo, Barbra Toro, Pavan K. Battiprolu, Pablo ...

Date : 01/02/2012 Item size : 398788 bytes

CaMKII can participate in arrhythmia signaling by effects on ion channel proteins, intracellular Ca2+ uptake and release, regulation of cell death, and by activation of hypertrophic signaling ...

Cardiovascular Research, Review in Review Focus Series on Calmodulin and Ca, Mark E. Anderson

Date : 01/03/2007 Item size : 444979 bytes

Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death Abstract Objective: The signaling pathways ...

Cardiovascular Research, Original Article, Frank Jung, Judith Haendeler, Christine Goebel, Andreas M. Zeiher, Stefanie Dimmeler

Date : 01/10/2000

Abstract Recent advances in the understanding of the molecular mechanisms of apoptosis has gained increasing interest in the cardiovascular research community. Apoptotic myocyte loss has been ...

Cardiovascular Research, Review, Armin Haunstetter, Seigo Izumo

Date : 01/02/2000

Abstract Aims Although a substantial role for 5 adenosine monophosphate-activated protein kinase (AMPK) has been established in regulating cardiac metabolism, a less studied action of AMPK is its ...

Cardiovascular Research, Original Article, Girish Kewalramani, Prasanth Puthanveetil, Fang Wang, Min Suk Kim, Sylvia Deppe, Ashraf Abrahani, Dan S. Luciani, James D. Johnson, Brian Rodrigues

Date : 01/10/2009

Anti-cancer anthracyclines such as doxorubicin (DOX) are associated with an increased and cumulative risk of cardiac damage, thereby limiting their usefulness.1,2 Approximately one in 10 patients ...

Cardiovascular Research, Cardiac biology and remodelling, Jie Wang, Mark W. Nachtigal, Elissavet Kardami, Peter A. Cattini

Date : 01/04/2013

Methods: Calpain activity and degradation of different structural proteins were studied along with the extent of necrosis in isolated rat hearts submitted to 60 min of ischemia and 30 min of ...

Cardiovascular Research, Research Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Luis Agulló, Pilar Pina, Jordi Soler-Soler

Date : 01/10/2004