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Methods: The effect of several concentrations of KB-R7943 added at reperfusion was studied in Fura-2 loaded quiescent cardiomyocytes submitted to 40 min of simulated ischemia (NaCN 2 mM, pH 6.4), and ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, José A Barrabés, Pilar Pina, Luis Agulló, Hans Michael Piper, Jordi ...

Date : 01/09/2002 Item size : 271773 bytes

Abstract Objective: Diminishing oxidative stress may protect the heart against ischaemiareperfusion injury by preventing opening of the mitochondrial permeability transition (MPT) pore. The ...

Cardiovascular Research, Original Article, Sabzali A. Javadov, Kelvin H.H. Lim, Paul M. Kerr, M.-Saadah Suleiman, Gianni D. Angelini, Andrew P. Halestrap

Date : 14/01/2000 Item size : 327545 bytes

Abstract Aims Several experimental studies have demonstrated protection against cardiac ischaemiareperfusion injury achieved by pre-treatment with exogenous sphingosine-1-phosphate ...

Cardiovascular Research, Original Article, Ulrich Hofmann, Natalie Burkard, Carolin Vogt, Annemarie Thoma, Stefan Frantz, Georg Ertl, Oliver Ritter, Andreas Bonz

Date : 15/07/2009 Item size : 284100 bytes

The research article which attracted our attention was by two pioneers in MPTP research, Fabio Di Lisa and Paulo Bernardi at the University of Padova.1 In their experimental study, they had ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Derek J. Hausenloy, Helen L. Maddock, Gary F. Baxter, Derek M. Yellon

Date : 01/11/2012 Item size : 280986 bytes

Methods and results The effect of acidic perfusion on reperfusion injury was studied in isolated rat hearts submitted to 40 min of ischaemia and 30 min of reperfusion, and its effect on the ...

Cardiovascular Research, ORIGINALS, Javier Inserte, Ignasi Barba, Víctor Hernando, Arancha Abellán, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, David Garcia-Dorado

Date : 01/03/2008

In this study, we examined the ability of IP to attenuate processing and activation of caspase-1 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP), after prolonged ischemia and ...

Cardiovascular Research, Original Article, Christophe A Piot, Jean-François Martini, Steve K Bui, Christopher L Wolfe

Date : 01/12/1999

Consistently, H2O2PC-attenuated I/R-induced cytosolic and mitochondrial Ca2+ overload, Ca2+ transient suppression, mitochondrial reactive oxygen species burst, and loss of mitochondrial inner ...

Cardiovascular Research, Cardiac biology and remodelling, Yixiong Chen, Jinlong Liu, Yanjun Zheng, Jinxi Wang, Zhihua Wang, Shanshan Gu, Jiliang Tan, Qing Jing, Huangtian Yang

Date : 01/02/2015

The primary protein kinase pathways that are potentially activated by myocardial ischemia/reperfusion include: the MAP kinases, ERK 1/2, JNK 1/2, p38 MAPKα/β; the cell survival kinase, Akt; and ...

Cardiovascular Research, Review, Stephen C Armstrong

Date : 15/02/2004

Introduction Na+H+ exchanger-1 (NHE-1) represents a major mechanism for H+ extrusion and pHi regulation under both normal physiological and pathological conditions, especially during ...

Cardiovascular Research, Original Article, Sabzali Javadov, Angel Choi, Venkatesh Rajapurohitam, Asad Zeidan, Alexei G. Basnakian, Morris Karmazyn

Date : 15/01/2008

Intravenous administration of the natriuretic peptide urodilatin at low doses during coronary reperfusion limits infarct size in anesthetized pigs KeywordsIschemiaNatriuretic ...

Cardiovascular Research, Original Article, Ferran Padilla, David Garcia-Dorado, Luis Agulló, José A Barrabés, Javier Inserte, Noelia Escalona, Markus Meyer, Maribel Mirabet, Pilar Pina, ...

Date : 15/08/2001