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Ehjcardiovascrec

Methods: The effect of several concentrations of KB-R7943 added at reperfusion was studied in Fura-2 loaded quiescent cardiomyocytes submitted to 40 min of simulated ischemia (NaCN 2 mM, pH 6.4), and ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, José A Barrabés, Pilar Pina, Luis Agulló, Hans Michael Piper, Jordi ...

Date : 01/09/2002 Item size : 271773 bytes
Ehjcardiovascrec

Preconditioning, a series of transient intervals of ischaemia and reperfusion applied before the lethal index ischaemic event, sets in motion molecular and cellular mechanisms that increase ...

Cardiovascular Research, Review, Asger Granfeldt, David J. Lefer, Jakob Vinten-Johansen

Date : 15/07/2009 Item size : 648421 bytes
Ehjcardiovascrec

Exposure of rat cardiac myoblasts to hydrogen peroxide caused an increase in PARS activity and cell injury/necrosis which was attenuated by pretreatment with the PARS ...

Cardiovascular Research, Original Article, Joanne Bowes, Michelle C. McDonald, Julie Piper, Christoph Thiemermann

Date : 01/01/1999 Item size : 246547 bytes
Ehjcardiovascrec

Abstract Objective: Diminishing oxidative stress may protect the heart against ischaemiareperfusion injury by preventing opening of the mitochondrial permeability transition (MPT) pore. The ...

Cardiovascular Research, Original Article, Sabzali A. Javadov, Kelvin H.H. Lim, Paul M. Kerr, M.-Saadah Suleiman, Gianni D. Angelini, Andrew P. Halestrap

Date : 14/01/2000 Item size : 327545 bytes
Ehjcardiovascrec

Abstract Aims It has been shown that sarcoplasmic reticulum calcium ATPase (SERCA) plays a critical role in reperfusion injury. [...]ischaemic post-conditioning (PoCo) results in protein kinase G ...

Cardiovascular Research, Cardiac biology and remodelling, Javier Inserte, Víctor Hernando, Marisol Ruiz-Meana, Marcos Poncelas-Nozal, Celia Fernández, Luis Agulló, Carmem Sartorio, Úrsula ...

Date : 01/09/2014 Item size : 366352 bytes
Ehjcardiovascrec

Abstract Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore ...

Cardiovascular Research, Review, Andrew P Halestrap, Samantha J Clarke, Sabzali A Javadov

Date : 15/02/2004 Item size : 445160 bytes
Ehjcardiovascrec

ROS and cellular redox conditions regulate a large number of vital pathways (energy metabolism, survival/stress responses, apoptosis, inflammatory response, oxygen sensing, etc). While cellular ...

Cardiovascular Research, Review, Lance B Becker

Date : 15/02/2004 Item size : 327763 bytes
Ehjcardiovascrec

The identification of the mechanisms of reperfusion-induced cell death opens a new window of opportunity for cardioprotection in the clinic. On the cellular level, it was shown that ...

Cardiovascular Research, Review, H.M Piper, Y Abdallah, C Schäfer

Date : 15/02/2004 Item size : 238908 bytes
Ehjcardiovascrec

Acute coronary occlusion resulting in myocardial infarction is the main mechanism by which coronary artery disease reduces survival and leads to deterioration of the quality of life, and the extent ...

Cardiovascular Research, Editorial, David Garcı́a-Dorado

Date : 15/02/2004 Item size : 147067 bytes
Ehjcardiovascrec

Despite its overall beneficial effect, experimental myocardial reperfusion was associated with prominent arrhythmias, enzyme release, and other adverse phenomena that were grouped under the imprecise ...

Cardiovascular Research, Viewpoint Editorial, David Garcia-Dorado, Hans Michael Piper

Date : 01/01/2006 Item size : 186761 bytes