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Pulmonary arterial hypertension (PAH) is a severe condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and death. An activation of ...

Cardiovascular Research, Review, Nazzareno Galié, Alessandra Manes, Angelo Branzi

Date : 01/02/2004 Item size : 434770 bytes

Receptors for S1P are also present in endothelial and smooth muscle cells where they mediate peripheral vascular tone and endothelial responses, but the role of this regulatory system in the cardiac ...

Cardiovascular Research, Review, Christopher K. Means, Joan Heller Brown

Date : 01/05/2009 Item size : 471982 bytes

Abstract Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. Introduction Atherosclerosis, an underlying ...

Cardiovascular Research, Review, Elizabeth J. Harvey, Dipak P. Ramji

Date : 01/07/2005 Item size : 433326 bytes

Abstract Many different stem cell types have been shown to differentiate into cardiac muscle cells in vitro but P19 embryonal carcinoma (EC) cells were one of the first examples described and have ...

Cardiovascular Research, Review, Marcel A.G. van der Heyden, Libert H.K. Defize

Date : 01/05/2003 Item size : 426088 bytes

Pharmacological studies have established that a blockade of the RAS at the level of the angiotensin-converting enzyme (ACE) or the AT1-receptor ameliorates the remodeling process of the heart and ...

Cardiovascular Research, Review, Kai C Wollert, Helmut Drexler

Date : 01/09/1999 Item size : 591071 bytes

[...]a consistent supply of translation-competent mRNA for these structural proteins to the polysomes is needed for normal cellular homeostasis, and it is essential for hypertrophic ...

Cardiovascular Research, Original Article, Dimitri Scholz, Paul McDermott, Maria Garnovskaya, Thomas N. Gallien, Stefan Huettelmaier, Christina DeRienzo, George Cooper

Date : 01/08/2006 Item size : 434904 bytes

[...]when cultured in the 3D-collagen gel system, FGF-induced p38 MAPK activation regulates tubulogenesis by possibly increasing apoptosis.4,5 Moreover, FGFs can induce cell-cycle arrest, ...

Cardiovascular Research, Review, Masahiro Murakami, Arye Elfenbein, Michael Simons

Date : 01/05/2008 Item size : 436433 bytes

Clinical and Regulatory Implications was held at the European Heart House in Sophia Antipolis, France, on the initiative of Günter Breithardt, FESC, FACC, on June 24th and 25th, 1999 after formal ...

Cardiovascular Research, Special article, Wilhelm Haverkamp, Günter Breithardt, A.John Camm, Michiel J Janse, Michael R Rosen, Charles Antzelevitch, Denis Escande, Michael Franz, Marek Malik, ...

Date : 01/08/2000 Item size : 431844 bytes

Studies conducted over the past dozen years or so have demonstrated that ventricular myocardium is not homogeneous, as previously thought, but is comprised of at least three electrophysiologically ...

Cardiovascular Research, Editorial, Charles Antzelevitch

Date : 01/06/2001 Item size : 290539 bytes

Introduction Mammalian heart function is regulated by the cooperative and dynamic interactions of two major cell types, cardiomyocytes (CMs) and cardiofibroblasts (FBs).1 CMs occupy nearly 75% of the ...

Cardiovascular Research, Original Article, Kangmin He, Xiaoli Shi, Xuejie Zhang, Song Dang, Xiaowei Ma, Fei Liu, Ming Xu, Zhizhen Lv, Dong Han, Xiaohong Fang, Youyi Zhang

Date : 01/10/2011 Item size : 287874 bytes