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In principle, activation of PI3Kγ and its downstream targets, like Akt, MEK, and the small GTPases of the Rac family, could also explain the ability of EPs to elicit a strong chemotactic response ...

Cardiovascular Research, Editorial, Emilio Hirsch, Alessandra Ghigo

Date : 01/04/2014 Item size : 146782 bytes

Elucidation of the functional denominators that link immune activation and derailed cholesterol metabolism may facilitate the development of novel therapeutic strategies to treat ...

Cardiovascular Research, Editorial, Saskia C.A. de Jager, Gerard Pasterkamp

Date : 01/10/2013 Item size : 176096 bytes

All members of the PDZLIM Enigma family, including ENH, are cytoplasmic proteins that bind to the cytoskeleton through a direct interaction between their PDZ domain and α-actinin,1 thus localizing ...

Cardiovascular Research, Editorial, Anne-Marie Lompré

Date : 01/06/2010 Item size : 162760 bytes

Animal as well as human studies have shown beneficial changes in biological phenomena related to cardiovascular health after the consumption of polyphenol-rich foods such as cocoa, red wine, tea, and ...

Cardiovascular Research, Editorial, José A. Páramo

Date : 01/07/2008 Item size : 165875 bytes

[...]the recent report by Babaei and Stewart [1] is in keeping with previous observations. More importantly, we have finally demonstrated that the conditioned media from SMC transfected with eNOS or ...

Cardiovascular Research, Letter to the Editor, Józef Dulak, Alicja Józkowicz

Date : 01/12/2002 Item size : 147610 bytes

The course of vascular calcification shares many features with that of bone mineralization, except that whereas skeletal mineralization is a physiological and highly regulated process, vascular ...

Cardiovascular Research, Editorial, Rhian M. Touyz, Augusto C. Montezano

Date : 01/02/2009 Item size : 175227 bytes

An extension of this traditional view is that the nature of the interstitial matrix may be to provide a hammock-like weave that, by its parallelogram structure, assists in protecting the muscle fibre ...

Cardiovascular Research, Editorial, Ian M.C. Dixon, Jared J.L. Davies

Date : 01/10/2011 Item size : 165710 bytes

VEGF was shown to affect an ever-growing list of non-endothelial cell types derived from all three embryonic lineages, includingto name a fewpneumocytes, retinal pigment epithelial cells, renal ...

Cardiovascular Research, Editorial, Filip Claes, Wouter Vandevelde, Lieve Moons, Marc Tjwa

Date : 01/08/2011 Item size : 174894 bytes

Chronic cardiotoxicity, which ranges from an incidence of 1% at a cumulative dose of 550 mg/m2 to >30% at cumulative doses above 5601160 mg/m2, can occur at any time after initiation of treatment and ...

Cardiovascular Research, Editorial, Charles F. McTiernan

Date : 01/02/2011 Item size : 177302 bytes

High-density lipoproteins (HDLs) have captured the imagination of scientists and physicians from virtually the time they were originally described, but especially after the cholesterol carried in HDL ...

Cardiovascular Research, Editorial, Daniel J. Rader

Date : 01/08/2014 Item size : 380769 bytes