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Ehjcardiovascrec

Introduction Fibroblasts are numerous within the healthy myocardium and are essential in the regulation of the extracellular matrix to maintain correct functioning of the heart.1,2 In cardiac ...

Cardiovascular Research, Original Article, James E. Cartledge, Christopher Kane, Priyanthi Dias, Meron Tesfom, Lucy Clarke, Benjamin Mckee, Samha Al Ayoubi, Adrian Chester, Magdi H. Yacoub, Patrizia ...

Date : 01/03/2015 Item size : 339824 bytes
Ehjcardiovascrec

Abstract Cardiac hypertrophy and fibrosis are two closely related adaptive response mechanisms of the myocardium to mechanical, metabolic, and genetic stress that finally contribute to the ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON HETEROCELLULAR SIGNALLING AND CROSSTALK IN THE HEART IN ISCHAEMIA AND HEART FAILURE, Janika Viereck, Claudia Bang, Ariana Foinquinos, Thomas ...

Date : 01/05/2014 Item size : 769285 bytes
Ehjcardiovascrec

Receptors for S1P are also present in endothelial and smooth muscle cells where they mediate peripheral vascular tone and endothelial responses, but the role of this regulatory system in the cardiac ...

Cardiovascular Research, Review, Christopher K. Means, Joan Heller Brown

Date : 01/05/2009 Item size : 471982 bytes
Ehjcardiovascrec

The growth in fibrous tissue content is based on the maintained proliferative potential of fibroblasts (largely absent in myocytes of the adult heart [3]), and the synthesis of extra-cellular matrix ...

Cardiovascular Research, Research Article, Patrizia Camelliti, Thomas K. Borg, Peter Kohl

Date : 01/01/2005 Item size : 422066 bytes
Ehjcardiovascrec

The large number of the extracellular signals and the intracellular pathways evoked represent potential drug targets. [...]the definition of the network of heterotypic cellular interactions in heart ...

Cardiovascular Research, Editorial, Emilio Hirsch, Ryozo Nagai, Thomas Thum

Date : 01/05/2014 Item size : 169401 bytes
Ehjcardiovascrec

An extension of this traditional view is that the nature of the interstitial matrix may be to provide a hammock-like weave that, by its parallelogram structure, assists in protecting the muscle fibre ...

Cardiovascular Research, Editorial, Ian M.C. Dixon, Jared J.L. Davies

Date : 01/10/2011 Item size : 165710 bytes
Ehjcardiovascrec

Excess production of ECM can severely inhibit organ function such as in Dupuytrens disease, scleroderma, hypertrophic scars, and cardiac fibrosis.1 Cardiac fibroblasts (CFs) are a predominant cell ...

Cardiovascular Research, Original Article, Nicole Gellings Lowe, James S. Swaney, Kelli M. Moreno, Roger A. Sabbadini

Date : 01/05/2009 Item size : 274664 bytes
Ehjcardiovascrec

Abstract Objective: Heart failure is characterized by an imbalance of matrix synthesis/turnover, finally resulting in fibrosis. Even though several reports identified TGF-β1 as a pro-fibrotic ...

Cardiovascular Research, Original Article, Philipp Stawowy, Christian Margeta, Heike Kallisch, Nabil G Seidah, Michel Chrétien, Eckart Fleck, Kristof Graf

Date : 01/07/2004
Ehjcardiovascrec

While different cardiac pathologies have been targeted with cell therapy, most data come from experimental and clinical studies on stem cell transplantation into the failing, infarcted ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON HETEROCELLULAR SIGNALLING AND CROSSTALK IN THE HEART IN ISCHAEMIA AND HEART FAILURE, Arti A. Ramkisoensing, Antoine A.F. de Vries, Douwe E. ...

Date : 01/05/2014
Ehjcardiovascrec

Caution should be used in extrapolating these model-system results to cardiac fibroblasts and myocytes in the native heart; both cell lines (HEK293 in Jia et al.7 and NIH-3T3 in Nussinovitch et ...

Cardiovascular Research, Editorial, Emilia Entcheva

Date : 01/06/2014