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Methods: Open chest dogs undergoing 15 min of left anterior descending coronary artery occlusion and 3 h of reperfusion were randomized to intracoronary infusions of 0.9% saline, vehicle, or the Ca2+ ...

Cardiovascular Research, Original Article, Steven C Smart, Kiran B Sagar, Jo El Schultz, David C Warltier, Larry R Jones

Date : 01/11/1997 Item size : 332368 bytes

Introduction Atherosclerotic plaque rupture, occurring either spontaneously or during coronary interventions, results in the release of atheromatous and/or thrombotic material into the coronary ...

Cardiovascular Research, Original Article, Andreas Skyschally, Rainer Schulz, Petra Gres, Ina Konietzka, Claus Martin, Michael Haude, Raimund Erbel, Gerd Heusch

Date : 01/08/2004 Item size : 260310 bytes

Abstract Objective: We tested the hypothesis that the rate of adaptation of coronary metabolic vasodilatation and autoregulation is modulated by the cardiac nerves. Reflex coronary vasodilatation ...

Cardiovascular Research, Original Article, Isabelle Vergroesen, Daphne Merkus, Jurgen W.G.E van Teeffelen, Jenny Dankelman, Jos A.E Spaan, Harry B van Wezel, Mark I.M Noble, Angela J Drake-Holland

Date : 01/12/1999 Item size : 244066 bytes

Abstract Background: Traffic of potentially harmful cytosolic messengers through gap junctions might cause increased injury during ischemia. The present study was to determine whether the infarct ...

Cardiovascular Research, Original Article, Tsung-Ming Lee, Mei-Shu Lin, Tsai-Fwu Chou, Chang-Her Tsai, Nen-Chung Chang

Date : 01/07/2004 Item size : 280862 bytes

Abstract Objective: The purpose of this study was to compare protective effects of AMP579 and adenosine (Ado) at reperfusion (R) on inhibition of polymorphonuclear neutrophil (PMN) activation, ...

Cardiovascular Research, Original Article, Jason M Budde, Daniel A Velez, Zhi-Qing Zhao, Kenneth L Clark, Cullen D Morris, Satoshi Muraki, Robert A Guyton, Jakob Vinten-Johansen

Date : 01/08/2000 Item size : 321171 bytes

Methods: We measured regional myocardial blood flow by the radioactive microsphere technique in seven anaesthetised dogs with an ultrasonic flowmeter on the circumflex branch of the left coronary ...

Cardiovascular Research, Original Article, M Mansaray, J.W Hynd, I Vergroesen, P.R Belcher, A.J Drake-Holland, M.I.M Noble

Date : 01/08/2000 Item size : 247900 bytes

Abstract This brief review summarizes the recently obtained evidence which illustrates the beneficial effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage and ...

Cardiovascular Research, Review, Russel J. Reiter, Dun-Xian Tan

Date : 01/04/2003 Item size : 397783 bytes

Abstract Objectives: Coronary collateral flow often mitigates the effects of coronary artery obstruction and has a significant impact on the prognosis of patients with coronary artery ...

Cardiovascular Research, Original Article, Kazuya Murata, Valmik Bhargava, François Ricou, Shiro Ono, Masashi Kambayashi, Byung-Hee Oh, Kirk L Peterson

Date : 01/02/1997 Item size : 243834 bytes

Abstract Objective: Because statins promote endogenous nitric oxide (NO) production in vessels by increasing endothelial nitric oxide synthase (eNOS), we evaluated the clinical benefit and efficiency ...

Cardiovascular Research, Original Article, Jean-Noel Trochu, Seema Mital, Xiao-ping Zhang, Xiaobin Xu, Manuel Ochoa, James K Liao, Fabio A Recchia, Thomas H Hintze

Date : 01/11/2003 Item size : 293750 bytes

Central to the definition of ischaemia is that coronary flow is not only insufficient to allow adequate energy production, but that the impaired flow also results in impaired removal of metabolic ...

Cardiovascular Research, Review, Pieter D Verdouw, Mirella A van den Doel, Sandra de Zeeuw, Dirk J Duncker

Date : 01/07/1998 Item size : 659320 bytes