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The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular ...

Cardiovascular Research, Review, Joerg Herrmann, Lilach O. Lerman, Amir Lerman

Date : 15/01/2010 Item size : 479470 bytes

[...]there is some evidence that the UPS itself modulates the activity of endothelial nitric oxide synthase, the key enzyme of vascular homeostasis, interacts with other vasoactive mediators involved ...

Cardiovascular Research, Review, Karl Stangl, Verena Stangl

Date : 15/01/2010 Item size : 509363 bytes

Introduction Primary pulmonary hypertension (PH) is a rare, progressive, and lethal disease of pulmonary vasculature characterized by enhanced vasoconstriction and vascular remodelling of small ...

Cardiovascular Research, Integrative physiology and pathophysiology, Krystyna Teichert-Kuliszewska, James N. Tsoporis, Jean-Francois Desjardins, Jun Yin, Liming Wang, Wolfgang M. Kuebler, Thomas G. ...

Date : 01/01/2015 Item size : 261468 bytes

The ubiquitin-proteasome system (UPS) plays a pivotal role in the complex molecular network regulating the progression both between and within each cell-cycle phase. [...]we will focus our attention ...

Cardiovascular Research, Review, Pasquale Fasanaro, Maurizio C. Capogrossi, Fabio Martelli

Date : 15/01/2010 Item size : 501466 bytes

Attenuation of EC responsiveness to insulin results from T-cad-mediated chronic activation of the Akt/mTOR-dependent negative feedback loop of the insulin cascade and enhanced degradation of the ...

Cardiovascular Research, Original Article, Maria Philippova, Manjunath B. Joshi, Dennis Pfaff, Emmanouil Kyriakakis, Kseniya Maslova, Paul Erne, Thérèse J. Resink

Date : 01/03/2012 Item size : 312788 bytes

A vicious cycle of inflammation and further oxidative stress results in increased endothelial permeability to lipoproteins and monocytes, and ultimately to atherosclerotic plaque development.1 ...

Cardiovascular Research, Vascular biology, Hayley Mylroie, Odile Dumont, Andrea Bauer, Clare C. Thornton, John Mackey, Damien Calay, Shahir S. Hamdulay, Joan R. Choo, Joseph J. Boyle, Allen M. ...

Date : 01/06/2015 Item size : 397507 bytes

Endothelial injury can give rise to endothelial dysfunction in which the profile of mediators released by endothelial cells is altered. Introduction The vascular endothelium is not an inert cellular ...

Cardiovascular Research, Review, Arántzazu Alfranca, Miguel A. Iñiguez, Manuel Fresno, Juan Miguel Redondo

Date : 01/06/2006 Item size : 488960 bytes

Studies assessing the effects of fibrates on endothelium have been neglected. [...]we conducted a trial in which the effects of fenofibrate and atorvastatin monotherapy on both endothelium-dependent ...

Cardiovascular Research, Original Article, Jan Malik, Vojtech Melenovsky, Dan Wichterle, Tomas Haas, Jan Simek, Richard Ceska, Jaromir Hradec

Date : 01/11/2001 Item size : 282627 bytes

There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

Here, we focus on the role of miRNA in vascular inflammation and remodelling associated with acute vascular injury (vein graft disease, angioplasty restenosis, and in-stent restenosis) as well as in ...

Cardiovascular Research, REVIEWS: FOCUS ON MICRORNA IN CARDIOVASCULAR BIOLOGY AND DISEASE, Robert A. McDonald, Akiko Hata, Margaret R. MacLean, Nicholas W. Morrell, Andrew H. Baker

Date : 15/03/2012 Item size : 449433 bytes