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The medial VSMC is the organizer of the inwardly directed angiogenic response arising from the adventitia by overexpressing vascular endothelial growth factor in response to lipid-stimulated ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON SMOOTH MUSCLE CELLS AND VASCULAR DISEASES, Patrick Lacolley, Véronique Regnault, Antonino Nicoletti, Zhenlin Li, Jean-Baptiste Michel

Date : 15/07/2012 Item size : 569256 bytes

Introduction Fibroblasts are numerous within the healthy myocardium and are essential in the regulation of the extracellular matrix to maintain correct functioning of the heart.1,2 In cardiac ...

Cardiovascular Research, Original Article, James E. Cartledge, Christopher Kane, Priyanthi Dias, Meron Tesfom, Lucy Clarke, Benjamin Mckee, Samha Al Ayoubi, Adrian Chester, Magdi H. Yacoub, Patrizia ...

Date : 01/03/2015 Item size : 339824 bytes

[...]understanding of the exact role of TGF-β signaling in the infarcted and remodeling heart has been hampered by the complex and unusual biology of TGF-β activation and by the diversity of ...

Cardiovascular Research, Review, Marcin Bujak, Nikolaos G. Frangogiannis

Date : 01/05/2007 Item size : 448075 bytes

The main purpose of these studies was the differentiation of cardiac precursor cells into specialized, differentiated cell types, as well as the development of functional properties such as Ca2+ ...

Cardiovascular Research, Review, J Hescheler, B.K Fleischmann, S Lentini, V.A Maltsev, J Rohwedel, A.M Wobus, K Addicks

Date : 01/11/1997 Item size : 528145 bytes

The resulting acute inflammation can induce an angiogenic response, producing a highly vascularized granulation tissue, as occurs during wound healing.1 Resolution of this inflammation and the onset ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Alicia G. Arroyo, M. Luisa Iruela-Arispe

Date : 01/05/2010 Item size : 513492 bytes

The molecular mechanisms involved in the lowering of Pif include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Rolf K. Reed, Kristofer Rubin

Date : 15/07/2010 Item size : 333953 bytes

[...]a wealth of new information has deepened our insight into the factors that govern the activity of the different signal transduction pathways. [...]the importance of cross-talk between signal ...

Cardiovascular Research, Review, Marc van Bilsen

Date : 01/12/1997 Item size : 585818 bytes

While physiological growth in the mature, adult heart may occur as a result of exercise, the bulk of hypertrophic myocardial growth is from pathological stress signals resulting from mechanical ...

Cardiovascular Research, Review, Robert S Ross

Date : 15/08/2004 Item size : 417902 bytes

The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myocardial ...

Cardiovascular Research, Review, Davy Vanhoutte, Mark Schellings, Yigal Pinto, Stephane Heymans

Date : 15/02/2006 Item size : 594416 bytes

Introduction The development of obliterative stenosis of vein grafts is primarily due to neointima formation and accelerated atherosclerosis.1,2 No successful therapeutic strategy to ameliorate vein ...

Cardiovascular Research, Vascular biology, Hong-Tao Shi, Ying Wang, Li-Xin Jia, Yan-Wen Qin, Yan Liu, Hui-Hua Li, Yong-Fen Qi, Jie Du

Date : 01/03/2014 Item size : 377860 bytes