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The incidence of plaque rupture and thrombotic events is largely correlated with specific morphological and histological features described for unstable plaques [1]. The structural components of ...

Cardiovascular Research, Review, Isabelle Gorenne, Mary Kavurma, Stephen Scott, Martin Bennett

Date : 01/10/2006 Item size : 478974 bytes

Abstract Aims Platelets are a natural source of growth factors, cytokines and chemokines, that regulate angiogenesis and inflammation. Methods and results The release of β-thromboglobulin, ...

Cardiovascular Research, Vascular biology, Thijs C. van Holten, Onno B. Bleijerveld, Patrick Wijten, Philip G. de Groot, Albert J.R. Heck, Arjan D. Barendrecht, Tesy H. Merkx, Arjen Scholten, Mark ...

Date : 01/07/2014 Item size : 210733 bytes

In disease states, fibroblast production of increased quantities of ECM proteins leads to tissue fibrosis, which can impair both mechanical and electrical function of the heart, contributing to heart ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Lixia Yue, Jia Xie, Stanley Nattel

Date : 01/03/2011 Item size : 519835 bytes

Circulating transforming growth factor β1 and coronary artery disease Methods: We explored the association between circulating plasma TGF-β1 measured by ELISA and coronary artery disease (CAD) ...

Cardiovascular Research, Original Article, X.L Wang, S.-X Liu, D.E.L Wilcken

Date : 01/05/1997 Item size : 191197 bytes

HIF-1 consists of O2-regulated HIF-1α and constitutively expressed HIF-1β subunits.1 HIF-2α is a HIF-1α paralogue that is also involved in vascular responses to ischaemia.2,3 In humans, ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Sergio Rey, Gregg L. Semenza

Date : 01/05/2010 Item size : 454352 bytes

Here, we assessed the differential expression of Kv currents between atrial and ventricular fibroblasts from control dogs and dogs with an atrial arrhythmogenic substrate caused by congestive heart ...

Cardiovascular Research, Ion channels and arrhythmias, Chia-Tung Wu, Xiao-Yan Qi, Hai Huang, Patrice Naud, Kristin Dawson, Yung-Hsin Yeh, Masahide Harada, Chi-Tai Kuo, Stanley Nattel

Date : 01/06/2014 Item size : 319683 bytes

Introduction Peripheral arterial disease (PAD) is a life-threatening problem in health care in aged societies.1 In the later stages of PAD, progression of tissue hypoperfusion leads to ischaemic ...

Cardiovascular Research, Original Article, Sung-Whan Kim, Hong-Zhe Zhang, Chae Eun Kim, Hyun Sook An, Jong-Min Kim, Moo Hyun Kim

Date : 01/03/2012 Item size : 277288 bytes

The platelet-derived growth factor (PDGF) BB is recognized as a major migratory factor for arterial SMCs both in vitro and during neointima formation. Since PDGF acts in synergy with the matrix ...

Cardiovascular Research, Original Article, Sandra Jalvy, Marie-Ange Renault, Laetitia Lam Shang Leen, Isabelle Belloc, Jacques Bonnet, Alain-Pierre Gadeau, Claude Desgranges

Date : 01/09/2007 Item size : 325661 bytes

Reactive oxygen species (ROS) such as superoxide and H2O2 function as signaling molecules in many aspects of growth factor-mediated responses including angiogenesis. Vascular endothelial growth ...

Cardiovascular Research, Review, Masuko Ushio-Fukai

Date : 15/07/2006 Item size : 528604 bytes

Methods Angiogenesis was assessed using in vitro parameters (i.e. endothelial cell proliferation, adhesion, transwell migration assay, scratched wound healing and formation of tube-like structure) ...

Cardiovascular Research, Original Article, Wen-Jie Cai, Ming-Jie Wang, Philip Keith Moore, Hui-Ming Jin, Tai Yao, Yi-Chun Zhu

Date : 01/10/2007 Item size : 301055 bytes