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Studies in small and large animal ischaemic heart disease models have reported that myocardial overexpression of VEGF following naked DNA transfection, Ad vectors, or AAV transduction induce ...

Cardiovascular Research, Review, Melvin Y. Rincon, Thierry VandenDriessche, Marinee K. Chuah

Date : 01/10/2015 Item size : 834056 bytes

Objective: Our aim was to evaluate the ability of a stabilized form of acidic fibroblast growth factor (aFGF-S117) to stimulate collateralization and arteriogenesis in the rabbit hindlimb following ...

Cardiovascular Research, Original Article, James C Hershey, Halea A Corcoran, Elizabeth P Baskin, David B Gilberto, Xianzhi Mao, Kenneth A Thomas, Jacquelynn J Cook

Date : 01/10/2003 Item size : 256610 bytes

Abstract Objective: The concept of therapeutic angiogenesis with vascular endothelial growth factor (VEGF) has been validated in peripheral arterial disease. Various doses of recombinant VEGF or AIA ...

Cardiovascular Research, Original Article, Bernard Malavaud, Ivan Tack, Frédéric Jonca, Françoise Praddaude, Françoise Moro, Jean-Louis Ader, Jean Plouët

Date : 01/11/1997 Item size : 247534 bytes

HIF-1 consists of O2-regulated HIF-1α and constitutively expressed HIF-1β subunits.1 HIF-2α is a HIF-1α paralogue that is also involved in vascular responses to ischaemia.2,3 In humans, ...

Cardiovascular Research, SPOTLIGHT REVIEWS, Sergio Rey, Gregg L. Semenza

Date : 01/05/2010 Item size : 454352 bytes

Angiogenesis by gene transfer provides an attractive alternative, with the advantage that the protein may continue to be secreted for a longer period of time and that the gene may be targeted to ...

Cardiovascular Research, Review, Basil S Lewis, Moshe Y Flugelman, Anat Weisz, Iris Keren-Tal, Wolfgang Schaper

Date : 01/09/1997

Introduction Improving angiogenesis and revascularization are therapeutic goals to rescue tissues from critical ischaemia and restore organ function.1 Neoangiogenesis initiates revascularization and ...

Cardiovascular Research, Original Article, Yi Tan, Yan Li, Jian Xiao, Hongwei Shao, Chuanlin Ding, Gavin E. Arteel, Keith A. Webster, Jun Yan, Hong Yu, Lu Cai, Xiaokun Li

Date : 01/06/2009

Deficiency of HIF-1α or HIF-1β in Tie2-lineage cells resulted in delayed wound closure, reduced vascularization, decreased cutaneous blood flow, impaired BMDAC mobilization, and decreased BMDAC ...

Cardiovascular Research, Original Article, Kakali Sarkar, Sergio Rey, Xianjie Zhang, Raul Sebastian, Guy P. Marti, Karen Fox-Talbot, Amanda V. Cardona, Junkai Du, Yee Sun Tan, Lixin Liu, Frank Lay, ...

Date : 01/01/2012

Abstract Objective: Previous investigations have shown the effectiveness of sustained intra- or extravascular administration of vascular endothelial growth factor (VEGF) in chronic myocardial ...

Cardiovascular Research, Original Article, John J Lopez, Roger J. Laham, Alon Stamler, Justin D Pearlman, Stuart Bunting, Aaron Kaplan, Joseph P Carrozza, Frank W Sellke, Michael Simons

Date : 01/11/1998

Methods and results The effects of locally injected S1P on blood flow recovery, angiogenesis, and vascular permeability in mouse ischaemic hindlimbs that underwent femoral arteriectomy were assessed ...

Cardiovascular Research, Original Article, Osamu Oyama, Naotoshi Sugimoto, Xun Qi, Noriko Takuwa, Kiyomi Mizugishi, Junji Koizumi, Yoh Takuwa

Date : 01/05/2008

Methods and results Mice lacking functional HO-1 (HO-1 showed reduced reparative neovascularization in ischaemic skeletal muscles, impaired blood flow (BF) recovery, and increased muscle cell death ...

Cardiovascular Research, Original Article, Agnieszka Jazwa, Jacek Stepniewski, Martin Zamykal, Jolanta Jagodzinska, Marco Meloni, Costanza Emanueli, Alicja Jozkowicz, Jozef Dulak

Date : 01/01/2013