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Ehjcardiovascrec

To evaluate whether a novel gene silencer pyrroleimidazole (PI) polyamide targeting transforming growth factor (TGF)-β1 is a candidate agent for the DESs, we examined the effects of PI polyamide ...

Cardiovascular Research, Original Article, En-Hui Yao, Noboru Fukuda, Takahiro Ueno, Hiroyuki Matsuda, Hiroki Nagase, Yoshiaki Matsumoto, Hiroshi Sugiyama, Koichi Matsumoto

Date : 01/03/2009 Item size : 295780 bytes
Ehjcardiovascrec

Atherosclerosis is epidemiologically linked and causally related to the presence of risk factors Despite their diversity, major risk factors for cardiovascular disease such as hypercholesterolaemia, ...

Cardiovascular Research, Editorial, Raffaele De Caterina, Rosalinda Madonna

Date : 01/03/2009 Item size : 231905 bytes
Ehjcardiovascrec

Short-term treatment of spontaneously hypertensive rats with liver growth factor reduces carotid artery fibrosis, improves vascular function, and lowers blood pressure When compared to those of ...

Cardiovascular Research, Original Article, Beatriz Somoza, Fatima Abderrahim, José M. González, M. Victoria Conde, Silvia M. Arribas, Barry Starcher, Javier Regadera, María S. ...

Date : 15/02/2006
Ehjcardiovascrec

In this study, we investigated the effect of trichostatin A (TSA), a potent HDAC inhibitor, on the proliferation and migration of vascular smooth muscle cells (VSMCs), and we examined the role of ...

Cardiovascular Research, Original Article, Seungjeong Song, Sang Won Kang, Chulhee Choi

Date : 01/01/2010
Ehjcardiovascrec

[...]we examined the effects of a chimeric DNARNA ribozyme targeting PDGF A-chain mRNA on neointima formation in rat carotid artery after balloon injury and evaluated its specificity for PDGF A-chain ...

Cardiovascular Research, Original Article, Motoko Kotani, Noboru Fukuda, Hideyuki Ando, Wen-Yang Hu, Satoshi Kunimoto, Satoshi Saito, Katsuo Kanmatsuse

Date : 01/01/2003
Ehjcardiovascrec

Metformin inhibited cardiac fibrosis (fibrosis area/total heart area: 0.6 ± 0.3 vs. 3.6 ± 0.9%, P < 0.01) induced by pressure overload and improved cardiac diastolic function (left ventricular ...

Cardiovascular Research, Original Article, Han Xiao, Xiaowei Ma, Wei Feng, Yongnan Fu, Zhizhen Lu, Ming Xu, Qiang Shen, Yi Zhu, Youyi Zhang

Date : 01/08/2010
Ehjcardiovascrec

Methods and results We employed chimeric decoy oligodeoxynucleotides (ODN) to inhibit both NFκB and E2F simultaneously, and examined the effects of chimeric decoy ODN on the proliferation and ...

Cardiovascular Research, Original Article, Takashi Miyake, Motokuni Aoki, Ryuichi Morishita

Date : 01/09/2008
Ehjcardiovascrec

Abstract Objective: Migration of vascular smooth muscle cells (VSMCs) from the tunica media to the intima is a key event in neointima formation after coronary artery angioplasty. Immunohistochemical ...

Cardiovascular Research, Research Article, Ramin Zargham, Gaétan Thibault

Date : 01/03/2005
Ehjcardiovascrec

While the role of vascular endothelial growth factor (VEGF) and its receptors VEGF-R1 (Flt-1) and VEGF-R2 (Flk-1) in this process has clearly been defined, expression of the VEGF-R3 (Flt-4) has only ...

Cardiovascular Research, Original Article, A. Schmeisser, M. Christoph, A. Augstein, R. Marquetant, M. Kasper, R.C. Braun-Dullaeus, R.H. Strasser

Date : 01/09/2006
Ehjcardiovascrec

In experiments in vitro, proliferation and migration of rabbit VSMCs that were stimulated by serum, angiotensin (AT) II, platelet-derived growth factor (PDGF)-BB, fibroblast growth factor (FGF), and ...

Cardiovascular Research, Original Article, Masakazu Shinohara, Seinosuke Kawashima, Tomoya Yamashita, Tomofumi Takaya, Ryuji Toh, Tatsuro Ishida, Tomomi Ueyama, Nobutaka Inoue, Ken-ichi Hirata, ...

Date : 01/11/2005