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Studies in small and large animal ischaemic heart disease models have reported that myocardial overexpression of VEGF following naked DNA transfection, Ad vectors, or AAV transduction induce ...

Cardiovascular Research, Review, Melvin Y. Rincon, Thierry VandenDriessche, Marinee K. Chuah

Date : 01/10/2015 Item size : 834056 bytes

Objective: Our aim was to evaluate the ability of a stabilized form of acidic fibroblast growth factor (aFGF-S117) to stimulate collateralization and arteriogenesis in the rabbit hindlimb following ...

Cardiovascular Research, Original Article, James C Hershey, Halea A Corcoran, Elizabeth P Baskin, David B Gilberto, Xianzhi Mao, Kenneth A Thomas, Jacquelynn J Cook

Date : 01/10/2003 Item size : 256610 bytes

[...]when cultured in the 3D-collagen gel system, FGF-induced p38 MAPK activation regulates tubulogenesis by possibly increasing apoptosis.4,5 Moreover, FGFs can induce cell-cycle arrest, ...

Cardiovascular Research, Review, Masahiro Murakami, Arye Elfenbein, Michael Simons

Date : 01/05/2008 Item size : 436433 bytes

Abstract Objective: The concept of therapeutic angiogenesis with vascular endothelial growth factor (VEGF) has been validated in peripheral arterial disease. Various doses of recombinant VEGF or AIA ...

Cardiovascular Research, Original Article, Bernard Malavaud, Ivan Tack, Frédéric Jonca, Françoise Praddaude, Françoise Moro, Jean-Louis Ader, Jean Plouët

Date : 01/11/1997 Item size : 247534 bytes

Vascular smooth muscle cells (VSMCs) are a major component of the arterial wall and play a critical role in the development of occlusive vascular lesions. [...]the administration of ET receptor ...

Cardiovascular Research, Editorial, Masafumi Takahashi

Date : 01/07/2006 Item size : 167199 bytes

Methods: Granulocyte-monocyte colony stimulating factor mobilized human CD34+ cells were isolated and grown in culture in the presence of vascular endothelial growth factor (50 ng/ml) and basic ...

Cardiovascular Research, Original Article, Danièle Nakul-Aquaronne, Jacques Bayle, Christian Frelin

Date : 01/03/2003 Item size : 208316 bytes

In an ordered and sequential manner, however, the embryo rapidly transforms into a highly vascular organism, survival being dependent on a functional, complex network of capillary plexuses and blood ...

Cardiovascular Research, Review, Edward M. Conway, Désiré Collen, Peter Carmeliet

Date : 16/02/2001 Item size : 588017 bytes

Abstract The central role of vascular endothelial growth factor (VEGF) in angiogenesis in health and disease makes it attractive both as a therapeutic target for anti-angiogenic drugs and as a ...

Cardiovascular Research, Review, Ian Zachary, Georgia Gliki

Date : 16/02/2001 Item size : 675767 bytes

Abstract Aims The embryonic epicardium is a source of smooth muscle cells and fibroblasts of the coronary vasculature and of the myocardium, but the signalling pathways that control mobilization and ...

Cardiovascular Research, Cardiac biology and remodelling, Carsten Rudat, Julia Norden, Makoto Mark Taketo, Andreas Kispert

Date : 01/12/2013

[...]we examined the effects of a chimeric DNARNA ribozyme targeting PDGF A-chain mRNA on neointima formation in rat carotid artery after balloon injury and evaluated its specificity for PDGF A-chain ...

Cardiovascular Research, Original Article, Motoko Kotani, Noboru Fukuda, Hideyuki Ando, Wen-Yang Hu, Satoshi Kunimoto, Satoshi Saito, Katsuo Kanmatsuse

Date : 01/01/2003