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Ehjcardiovascrec

Studies in small and large animal ischaemic heart disease models have reported that myocardial overexpression of VEGF following naked DNA transfection, Ad vectors, or AAV transduction induce ...

Cardiovascular Research, Review, Melvin Y. Rincon, Thierry VandenDriessche, Marinee K. Chuah

Date : 01/10/2015 Item size : 834056 bytes
Ehjcardiovascrec

The demonstration that gene therapy can improve collateral function presents one of the solutions to the conundrum, since gene therapy can be considered a sophisticated form of a sustained delivery ...

Cardiovascular Research, Review, Stephen E. Epstein, Shmuel Fuchs, Yi Fu Zhou, Richard Baffour, Ran Kornowski

Date : 16/02/2001 Item size : 488164 bytes
Ehjcardiovascrec

Conclusion This study shows that proangiogenic gene therapy can significantly improve performance of ischaemic limbs and supports the concept of therapeutic angiogenesis for the treatment of patients ...

Cardiovascular Research, Original Article, Petra Korpisalo, Tuomas T. Rissanen, Timo Bengtsson, Timo Liimatainen, Svetlana Laidinen, Henna Karvinen, Johanna E. Markkanen, Olli H. Gröhn, Seppo ...

Date : 01/11/2008 Item size : 249276 bytes
Ehjcardiovascrec

[...]we examined the effects of a chimeric DNARNA ribozyme targeting PDGF A-chain mRNA on neointima formation in rat carotid artery after balloon injury and evaluated its specificity for PDGF A-chain ...

Cardiovascular Research, Original Article, Motoko Kotani, Noboru Fukuda, Hideyuki Ando, Wen-Yang Hu, Satoshi Kunimoto, Satoshi Saito, Katsuo Kanmatsuse

Date : 01/01/2003
Ehjcardiovascrec

Clinical gene therapy studies have been challenged by the relatively short duration of gene expression in some systems, as well as by the suboptimal distribution of gene expression, and have failed ...

Cardiovascular Research, Editorial, John J. Pacella, Andrew R. Carson

Date : 01/09/2012
Ehjcardiovascrec

Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA Abstract Objective: Previous studies have ...

Cardiovascular Research, Review, Hirotsugu Tabata, Marcy Silver, Jeffrey M Isner

Date : 01/09/1997
Ehjcardiovascrec

The primary goal of therapy for patients with acute myocardial infarction is rapid revascularization of ischemic tissue. Since thrombolytic therapy or catheter-based intervention can only accomplish ...

Cardiovascular Research, Editorial, Ioakim Spyridopoulos

Date : 01/01/2005
Ehjcardiovascrec

Table 1 summarises phase II angiogenesis gene therapy trials that have been completed for both coronary and peripheral artery disease. [...]angiogenesis gene therapy has quietly reached the era of ...

Cardiovascular Research, Editorial, Sigrid Nikol

Date : 01/02/2007
Ehjcardiovascrec

Methods and results Mice lacking functional HO-1 (HO-1 showed reduced reparative neovascularization in ischaemic skeletal muscles, impaired blood flow (BF) recovery, and increased muscle cell death ...

Cardiovascular Research, Original Article, Agnieszka Jazwa, Jacek Stepniewski, Martin Zamykal, Jolanta Jagodzinska, Marco Meloni, Costanza Emanueli, Alicja Jozkowicz, Jozef Dulak

Date : 01/01/2013
Ehjcardiovascrec

Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA Abstract Objective: Previous studies have ...

Cardiovascular Research, Tabata, Hirotsugu, Silver, Marcy, Isner, Jeffrey M

Date : 01/09/1997