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Ehjcardiovascrec

miRNAs influence key physiological processes, such as proliferation, migration, differentiation, secretion, excitation, conduction, cell cycle, and apoptosis, by altering protein expression of ...

Cardiovascular Research, REVIEWS: FOCUS ON MICRORNA IN CARDIOVASCULAR BIOLOGY AND DISEASE, S. Dangwal, C. Bang, T. Thum

Date : 15/03/2012 Item size : 441676 bytes
Ehjcardiovascrec

Abstract Objective:: Transforming growth factor (TGF)-β promotes the deposition of extracellular matrix protein and also acts as an anti-inflammatory cytokine. Methods:: Anterior MI was produced ...

Cardiovascular Research, Research Article, Masaki Ikeuchi, Hiroyuki Tsutsui, Tetsuya Shiomi, Hidenori Matsusaka, Shouji Matsushima, Jing Wen, Toru Kubota, Akira Takeshita

Date : 01/12/2004 Item size : 252606 bytes
Ehjcardiovascrec

Many experimental approaches have used growth factor induction, either as proteins or as DNA vectors, in an attempt to increase the local blood supply via induction of an improved capillary bed by ...

Cardiovascular Research, Editorial, Anton J.G. Horrevoets

Date : 01/12/2008 Item size : 167280 bytes
Ehjcardiovascrec

[...]anti-fibrotic strategies are increasingly recognized as a promising approach in the prevention and treatment of heart failure. [...]dissecting the molecular mechanisms underlying the ...

Cardiovascular Research, Review, Esther E. Creemers, Yigal M. Pinto

Date : 01/02/2011 Item size : 426359 bytes
Ehjcardiovascrec

In disease states, fibroblast production of increased quantities of ECM proteins leads to tissue fibrosis, which can impair both mechanical and electrical function of the heart, contributing to heart ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Lixia Yue, Jia Xie, Stanley Nattel

Date : 01/03/2011 Item size : 519835 bytes
Ehjcardiovascrec

Several risk factors modify the progression of hypertrophy, the associated progressive impairment of myocardial function, and eventually the transition to overt congestive heart failure. Endpoints ...

Cardiovascular Research, Original Article, K. Meurrens, S. Ruf, G. Ross, R. Schleef, K. von Holt, K.-D. Schlüter

Date : 01/11/2007
Ehjcardiovascrec

Metformin inhibited cardiac fibrosis (fibrosis area/total heart area: 0.6 ± 0.3 vs. 3.6 ± 0.9%, P < 0.01) induced by pressure overload and improved cardiac diastolic function (left ventricular ...

Cardiovascular Research, Original Article, Han Xiao, Xiaowei Ma, Wei Feng, Yongnan Fu, Zhizhen Lu, Ming Xu, Qiang Shen, Yi Zhu, Youyi Zhang

Date : 01/08/2010
Ehjcardiovascrec

1 Introduction Heart failure represents one of the most frequent cardiovascular diseases in the world that develops as a result of the inability of the heart to pump enough blood to maintain ...

Cardiovascular Research, Review, Agapios Sachinidis, Bernd K. Fleischmann, Eugen Kolossov, Maria Wartenberg, Heinrich Sauer, Jürgen Hescheler

Date : 01/05/2003
Ehjcardiovascrec

Typical medication that helps systolic HF (HF with reduced EF, HFREF) patients, such as beta-blockade and angiotensin-converting enzyme inhibitors, are not successful in HFPEF patients.1 HFPEF is ...

Cardiovascular Research, Editorial, Dirk Westermann, Stephane Heymans

Date : 15/07/2014
Ehjcardiovascrec

Despite the current extensive armamentum of pharmacological interventions available to the clinician to combat this syndrome, the prognosis for patients who manage to survive the acute phase of a ...

Cardiovascular Research, Editorial, Ian M.C. Dixon

Date : 01/07/2001