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Pre-treatment with IL-6 receptor (IL-6R)-blocking antibody (anti-IL-6R Ab) inhibited EAM induction in terms of disease severity score (3.5 ± 0.8; IgG vs. 0.5 ± 0.8; anti-IL-6R Ab, n = 6, P< ...

Cardiovascular Research, Original Article, Tomomi Yamashita, Tomohiko Iwakura, Kazuki Matsui, Haruyo Kawaguchi, Masanori Obana, Akiko Hayama, Makiko Maeda, Yasukatsu Izumi, Issei Komuro, Yoshiyuki ...

Date : 01/09/2011 Item size : 250705 bytes

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

Methods and results The following parameters were evaluated: (i) number of ventricular arrhythmias in resting and stress conditions (restraint test) or after aconitine administration; (ii) cardiac ...

Cardiovascular Research, Original Article, Claudia Colussi, Roberta Berni, Jessica Rosati, Stefania Straino, Serena Vitale, Francesco Spallotta, Silvana Baruffi, Leonardo Bocchi, Francesca Delucchi, ...

Date : 01/07/2010 Item size : 280000 bytes

Water and sodium regulation in chronic heart failure: the role of natriuretic peptides and vasopressin KeywordsHeart failureNatriuretic peptideVasoconstriction/dilationAntihypertensive/diuretic ...

Cardiovascular Research, Review, Paul R Kalra, Stefan D Anker, Andrew J.S Coats

Date : 15/08/2001 Item size : 668395 bytes

Evidence is now emerging that hyperphosphorylation of the cardiac ryanodine receptor is an important event in chronic heart failure, contributing to impaired contraction and the generation of ...

Cardiovascular Research, Review, Mark Scoote, Alan J Williams

Date : 01/12/2002 Item size : 402108 bytes

[...]nucleoporin (Nup) p62 was increased in ICM (80%) and DCM (109%) (P < 0.001 and P = 0.024). Introduction Heart failure (HF) has been associated with changes in glycolytic enzymes, mitochondria, ...

Cardiovascular Research, Original Article, Raquel Cortés, Esther Roselló-Lletí, Miguel Rivera, Luis Martínez-Dolz, Antonio Salvador, Inmaculada Azorín, Manuel Portolés

Date : 01/02/2010 Item size : 276957 bytes

Possible reasons for this decreased sensitivity to injury are discussed, which include a decreased accumulation of glycolytic products during ischemia (lactate and protons), as well as alterations in ...

Cardiovascular Research, Review, Danielle Feuvray, Gary D Lopaschuk

Date : 01/04/1997 Item size : 189407 bytes

In the isolated perfused hearts of five of these 14 mice cytosolic and mitochondrial ATP/ADP-ratios, determined by nonaqueous fractionation, were significantly altered, signalling a reduced ANT ...

Cardiovascular Research, Original Article, Karsten Schulze, Bernhard Witzenbichler, Claudia Christmann, Heinz-Peter Schultheiss

Date : 01/10/1999 Item size : 294407 bytes

Methods: MI was induced by permanent ligation of the left coronary artery in male normotensive Wistar rats. At these time points, mean arterial blood pressure (MAP), heart rate (HR), left ...

Cardiovascular Research, Original Article, Steffen Sandmann, Jiang-Yong Min, Achim Meissner, Thomas Unger

Date : 01/10/1999 Item size : 409874 bytes

Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes