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A shift of the balance between dilator and constrictor influences may also be crucial for the development of endothelial dysfunction in heart failure. Reduced endothelium-dependent vasodilator ...

Cardiovascular Research, Bauersachs, Johann, Fraccarollo, Daniela, Galuppo, Paolo, Widder, Julian, Ertl, Georg

Date : 01/07/2000 Item size : 260534 bytes

In human and experimental myocardial infarction (MI), cessation of blood supply leads to rapid necrosis of cardiac myocytes in the ischaemic heart. Despite aggressive primary therapy, prognosis ...

Cardiovascular Research, Frantz, Stefan, Bauersachs, Johann, Ertl, Georg

Date : 15/02/2009 Item size : 150175 bytes

Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy Abstract Objectives: We investigated the effects of ...

Cardiovascular Research, Fraccarollo, Daniela, Bauersachs, Johann, Kellner, Markus, Galuppo, Paolo, Ertl, Georg

Date : 01/04/2002

Despite aggressive primary therapy, prognosis remains poor in patients with large infarction and severe left ventricular dysfunction. [...]it would be highly desirable to improve healing of the ...

Cardiovascular Research, Frantz, Stefan, Bauersachs, Johann, Ertl, Georg

Date : 15/02/2009 Item size : 387729 bytes

In rings from rats with heart failure, acetylcholine-induced relaxation was attenuated (maximum relaxation, Rmax 54±3%) when compared with rings from sham-operated animals (79±3%, n=12, ...

Cardiovascular Research, Bauersachs, Johann, Fleming, Ingrid, Fraccarollo, Daniela, Busse, Rudi, Ertl, Georg

Date : 01/08/2001

Abstract Objectives: The mechanisms underlying the clinical benefits of mineralocorticoid receptor antagonism in patients with left ventricular (LV) dysfunction and heart failure (CHF) after ...

Cardiovascular Research, Fraccarollo, Daniela, Galuppo, Paolo, Schmidt, Isabel, Ertl, Georg, Bauersachs, Johann

Date : 01/07/2005 Item size : 341490 bytes

In mice with PPCM due to a cardiomyocyte-specific knockout of STAT3 (CKO) neither low nor high dose of recombinant Relaxin-2 (serelaxin, sRlx-LD: 30 µg/kg/day; sRlx-HD: 300 µg/kg/day) affected ...

Cardiovascular Research, Nonhoff, Justus, Ricke-Hoch, Melanie, Mueller, Mirco, Stapel, Britta, Pfeffer, Tobias, Kasten, Martina, Scherr, Michaela, von Kaisenberg, Constantin, Bauersachs, Johann, ...

Date : 01/05/2017 Item size : 355989 bytes

Abstract Objectives: Hypercholesterolemia contributes to coronary artery disease progression but little is known about its effect on left ventricular (LV) function after myocardial infarction ...

Cardiovascular Research, Bauersachs, Johann, Hiss, Katrin, Fraccarollo, Daniela, Laufs, Ulrich, Ruetten, Hartmut

Date : 01/12/2006

Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent Abstract Objective: The mitogen-activated protein (MAP) kinase system, especially the ...

Cardiovascular Research, Widder, Julian, Behr, Thomas, Fraccarollo, Daniela, Hu, Kai, Galuppo, Paolo, Tas, Piet, Angermann, Christiane E, Ertl, Georg, Bauersachs, Johann

Date : 01/07/2004 Item size : 251632 bytes

Abstract Objectives: To investigate the effects of adding the selective aldosterone receptor antagonist eplerenone to ACE inhibition on endothelium-dependent vasodilation in rats with chronic heart ...

Cardiovascular Research, Schäfer, Andreas, Fraccarollo, Daniela, Hildemann, Steven K, Tas, Piet, Ertl, Georg, Bauersachs, Johann

Date : 01/06/2003 Item size : 291946 bytes