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Introduction Sarcolemmal Na+Ca2+ exchange plays a pivotal role in ion transport of the myocardium which is crucial for cardiac contractile performance. Recently, it has been recognized that Ca2+ as ...

Cardiovascular Research, Schillinger, Wolfgang, Fiolet, Jan W, Schlotthauer, Klaus, Hasenfuss, Gerd

Date : 15/03/2003 Item size : 489490 bytes

Abstract Background: Pyruvate has been shown to increase contractile function in isolated myocardium and to improve hemodynamics in patients with congestive heart failure. Conclusion: A combination ...

Cardiovascular Research, Hermann, Hans-Peter, Zeitz, Oliver, Lehnart, Stephan E, Keweloh, Boris, Datz, Nicolin, Hasenfuss, Gerd, Janssen, Paul M.L

Date : 01/01/2002

Na+–Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury Abstract Objective: In heart failure (HF), the generation of reactive oxygen species (ROS) is ...

Cardiovascular Research, Wagner, Stefan, Seidler, Tim, Picht, Eckard, Maier, Lars S, Kazanski, Victor, Teucher, Nils, Schillinger, Wolfgang, Pieske, Burkert, Isenberg, Gerrit, Hasenfuss, Gerd, ...

Date : 01/11/2003

Abstract The progress made in our understanding of the pathophysiology and treatment of congestive heart failure (CHF) would not have been possible without a number of animal models of heart failure ...

Cardiovascular Research, Hasenfuss, Gerd

Date : 01/07/1998

Time for primary review 27 days. 1 Introduction During the last decade there was accumulating evidence that alterations of excitation-contraction (EC) coupling may play a critical role in the ...

Cardiovascular Research, Hasenfuss, Gerd

Date : 01/02/1998

Abstract Objective: Increased levels of inhibitory G proteins have been observed in heart failure, but their physiological relevance in mediating the reduced β-adrenergic response is largely ...

Cardiovascular Research, Janssen, Paul M.L, Schillinger, Wolfgang, Donahue, J.Kevin, Zeitz, Oliver, Emami, Shahriyar, Lehnart, Stephan E, Weil, Joachim, Eschenhagen, Thomas, Hasenfuss, Gerd, Prestle, ...

Date : 01/08/2002 Item size : 274405 bytes

Introduction Clinical and preclinical evidence suggests that inadequate cardiac angiogenesis is an important determinant of heart failure. 1 It is regulated by angiogenic growth factors released from ...

Cardiovascular Research, Gogiraju, Rajinikanth, Schroeter, Marco R., Bochenek, Magdalena L., Hubert, Astrid, Münzel, Thomas, Hasenfuss, Gerd, Schäfer, Katrin

Date : 01/08/2016 Item size : 372193 bytes

Notably, I-1-KO were partially protected from lethal catecholamine-induced arrhythmias and from hypertrophy and dilation induced by a 7 day infusion with the β-adrenergic agonist ...

Cardiovascular Research, El-Armouche, Ali, Wittköpper, Katrin, Degenhardt, Franziska, Weinberger, Florian, Didié, Michael, Melnychenko, Ivan, Grimm, Michael, Peeck, Micha, Zimmermann, Wolfram ...

Date : 01/12/2008 Item size : 334652 bytes

[...]in the mouse model, histological determination of myocyte diameter, heart weight/body weight ratio, and echocardiographic measurements revealed that myocardial expression of DYRK1A failed to ...

Cardiovascular Research, Grebe, Cornelia, Klingebiel, Theda-Maria, Grau, Simon Philipp, Toischer, Karl, Didié, Michael, Jacobshagen, Claudius, Dullin, Christian, Hasenfuss, Gerd, Seidler, Tim

Date : 01/06/2011 Item size : 264031 bytes

Methods: Subepicardial (epi), midmyocardial (mid), and subendocardial (endo) sections of the left ventricular free wall from end-stage failing (n=17) and nonfailing (n=5) human hearts were analyzed ...

Cardiovascular Research, Prestle, Jürgen, Dieterich, Sabine, Preuss, Michael, Bieligk, Ursula, Hasenfuss, Gerd

Date : 01/08/1999