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In rings from rats with heart failure, acetylcholine-induced relaxation was attenuated (maximum relaxation, Rmax 54±3%) when compared with rings from sham-operated animals (79±3%, n=12, ...

Cardiovascular Research, Original Article, Johann Bauersachs, Ingrid Fleming, Daniela Fraccarollo, Rudi Busse, Georg Ertl

Date : 01/08/2001 Item size : 280141 bytes

Abstract Objectives: The mechanisms underlying the clinical benefits of mineralocorticoid receptor antagonism in patients with left ventricular (LV) dysfunction and heart failure (CHF) after ...

Cardiovascular Research, Original Article, Daniela Fraccarollo, Paolo Galuppo, Isabel Schmidt, Georg Ertl, Johann Bauersachs

Date : 01/07/2005 Item size : 310967 bytes

Adverse remodelling of the heart associated with hypertension, valve disease, or myocardial infarction includes diverse functional, structural, and metabolic abnormalities, such as sarcomere ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Johann Bauersachs

Date : 01/11/2012 Item size : 172663 bytes

Abstract Objectives: To investigate the effects of adding the selective aldosterone receptor antagonist eplerenone to ACE inhibition on endothelium-dependent vasodilation in rats with chronic heart ...

Cardiovascular Research, Original Article, Andreas Schäfer, Daniela Fraccarollo, Steven K Hildemann, Piet Tas, Georg Ertl, Johann Bauersachs

Date : 01/06/2003

Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy Abstract Objectives: We investigated the effects of ...

Cardiovascular Research, Original Article, Daniela Fraccarollo, Johann Bauersachs, Markus Kellner, Paolo Galuppo, Georg Ertl

Date : 01/04/2002

In mice with PPCM due to a cardiomyocyte-specific knockout of STAT3 (CKO) neither low nor high dose of recombinant Relaxin-2 (serelaxin, sRlx-LD: 30 µg/kg/day; sRlx-HD: 300 µg/kg/day) affected ...

Cardiovascular Research, Original Article, Justus Nonhoff, Melanie Ricke-Hoch, Mirco Mueller, Britta Stapel, Tobias Pfeffer, Martina Kasten, Michaela Scherr, Constantin von Kaisenberg, Johann ...

Date : 20/01/2017

Abstract Objectives: To elucidate the effect of selective endothelin ETA- and mixed ETA/B-receptor antagonists on endothelial vasomotor dysfunction in rats with heart failure after myocardial ...

Cardiovascular Research, Original Article, Johann Bauersachs, Daniela Fraccarollo, Paolo Galuppo, Julian Widder, Georg Ertl

Date : 01/07/2000

Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent Abstract Objective: The mitogen-activated protein (MAP) kinase system, especially the ...

Cardiovascular Research, Original Article, Julian Widder, Thomas Behr, Daniela Fraccarollo, Kai Hu, Paolo Galuppo, Piet Tas, Christiane E Angermann, Georg Ertl, Johann Bauersachs

Date : 01/07/2004

Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure Abstract Objective: Innate immune response proteins such as inflammatory cytokines, inducible nitric ...

Cardiovascular Research, Original Article, Stefan Frantz, Daniela Fraccarollo, Helga Wagner, Thomas M Behr, Philip Jung, Christiane E Angermann, Georg Ertl, Johann Bauersachs

Date : 01/03/2003

Sensitivity to ischaemia varies among myocardial cells, vasculature, and connective tissue adding to inhomogeneity of infarct tissue composition.2 In addition, inflammatory cells and macrophages may ...

Cardiovascular Research, Review, Stefan Frantz, Johann Bauersachs, Georg Ertl

Date : 15/02/2009