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An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes

For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Review, Elizabeth A. Woodcock, Xiao-Jun Du, Melissa E. Reichelt, Robert M. Graham

Date : 01/02/2008 Item size : 499739 bytes

Abstract Transmembrane voltage-gated Ca2+ channels play a central role in the development and control of heart contractility which is modulated by the concentration of free cytosolic calcium ions ...

Cardiovascular Research, Review, Sylvain Richard, Florence Leclercq, Stéphanie Lemaire, Christophe Piot, Joël Nargeot

Date : 01/02/1998 Item size : 481600 bytes

KeywordsArrhythmia (mechanisms)Contractile functionHeart failureHypertrophyNa/H-exchangerNa/K-pumpTime for primary review 26 days. 1 [Na]i in hypertrophy and heart failure Myocardial hypertrophy ...

Cardiovascular Research, Review, Steven M Pogwizd, Karin R Sipido, Fons Verdonck, Donald M Bers

Date : 15/03/2003 Item size : 394084 bytes

Pharmacological studies have established that a blockade of the RAS at the level of the angiotensin-converting enzyme (ACE) or the AT1-receptor ameliorates the remodeling process of the heart and ...

Cardiovascular Research, Review, Kai C Wollert, Helmut Drexler

Date : 01/09/1999 Item size : 591071 bytes

Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes

Abstract The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and ...

Cardiovascular Research, Review, Petronila Penela, Cristina Murga, Catalina Ribas, Antonio S. Tutor, Sandra Peregrín, Federico Mayor

Date : 01/01/2006 Item size : 407122 bytes

KeywordsAntihypertensive agentsHeart rate (variability)HemodynamicsHypertensionHypertrophyVentricular function 1 Introductory remarks Left ventricular hypertrophy (LVH) was recognized as early as in ...

Cardiovascular Research, Update review, P.A. van Zwieten

Date : 01/01/2000 Item size : 366202 bytes