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The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myocardial ...

Cardiovascular Research, Review, Davy Vanhoutte, Mark Schellings, Yigal Pinto, Stephane Heymans

Date : 15/02/2006 Item size : 594416 bytes

During ventricular remodelling following sustained periods of pressure overload, cardiac fibroblasts become activated and start producing excessive amounts of ECM proteins, such as fibrillar ...

Cardiovascular Research, Cardiac biology and remodelling, Kate M. Herum, Ida G. Lunde, Biljana Skrbic, William E. Louch, Almira Hasic, Sigurd Boye, Andreas Unger, Sverre-Henning Brorson, Ivar ...

Date : 01/05/2015 Item size : 354118 bytes

AII also has multiple effects on cardiac fibroblasts: it induces cardiac fibroblast proliferation, synthesis and secretion of adhesion molecules and extracellular matrix proteins, and expression of ...

Cardiovascular Research, Review, Janet M. Schnee, Willa A. Hsueh

Date : 01/05/2000 Item size : 271507 bytes

The large number of the extracellular signals and the intracellular pathways evoked represent potential drug targets. [...]the definition of the network of heterotypic cellular interactions in heart ...

Cardiovascular Research, Editorial, Emilio Hirsch, Ryozo Nagai, Thomas Thum

Date : 01/05/2014 Item size : 169401 bytes

Abstract Aims Cardiac fibrosis contributes to the transition from compensated ventricular hypertrophy to heart failure, which can be promoted by connective tissue growth factor (CTGF). Introduction ...

Cardiovascular Research, Original Article, Xuehui Liu, Yingli Gai, Fei Liu, Wei Gao, Youyi Zhang, Ming Xu, Zhaoping Li

Date : 01/10/2010 Item size : 306561 bytes

Conclusions Our data provide important insights into the regulation of pro-inflammatory cytokine expression in human cardiac fibroblasts and suggest that the myocardial anti-inflammatory effects of ...

Cardiovascular Research, Original Article, Neil A. Turner, Romana S. Mughal, Philip Warburton, David J. O'Regan, Stephen G. Ball, Karen E. Porter

Date : 01/10/2007 Item size : 317459 bytes

Introduction Cardiac remodelling after long-term pressure overload results in ventricular dysfunction and heart failure, which results in poor outcome and high mortality.1 One common characteristic ...

Cardiovascular Research, Original Article, Li Li, Dong Fan, Cheng Wang, Jin-Yu Wang, Xiao-Bing Cui, Dan Wu, Yun Zhou, Li-Ling Wu

Date : 01/07/2011 Item size : 293532 bytes

Abstract Objective: The aim of this study was to determine whether chronic β-adrenergic receptor (β-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the ...

Cardiovascular Research, Original Article, Neil A Turner, Karen E Porter, William H.T Smith, Hazel L White, Stephen G Ball, Anthony J Balmforth

Date : 01/03/2003 Item size : 274405 bytes

In adults, EPO is produced primarily in the kidney via an oxygen-sensing mechanism and stimulates erythroid progenitors in the bone marrow to increase red blood cell mass. The therapeutic relevance ...

Cardiovascular Research, Editorial, Qingping Feng

Date : 01/09/2006 Item size : 169639 bytes

Adverse remodelling of the heart associated with hypertension, valve disease, or myocardial infarction includes diverse functional, structural, and metabolic abnormalities, such as sarcomere ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Johann Bauersachs

Date : 01/11/2012 Item size : 172663 bytes