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Ehjcardiovascrec

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes
Ehjcardiovascrec

[...]the identification of key processes setting off a cascade of detrimental cellular changes, ultimately leading to the development of cardiac failure, is still subject of intense research. The ...

Cardiovascular Research, Review, Marc van Bilsen, Pascal J.H Smeets, Andries J Gilde, Ger J van der Vusse

Date : 01/02/2004 Item size : 428514 bytes
Ehjcardiovascrec

The orderly T-tubule network guarantees the instantaneous excitation and synchronous activation of nearly all Ca2+ release sites throughout the large ventricular myocyte. Because of the critical ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE, Ang Guo, Caimei Zhang, Sheng Wei, Biyi Chen, ...

Date : 01/05/2013 Item size : 559877 bytes
Ehjcardiovascrec

Programmed cell death (apoptosis) of cardiac muscle cells has been identified as an essential process in the progression to heart failure. [...]the present review summarizes the apoptotic pathways ...

Cardiovascular Research, Review, Vanessa P.M. van Empel, Anne T.A. Bertrand, Leo Hofstra, Harry J. Crijns, Pieter A. Doevendans, Leon J. De Windt

Date : 01/07/2005 Item size : 392260 bytes
Ehjcardiovascrec

Abstract Proper contractile function of the heart depends on intact excitationcontraction processes and ion homeostasis of the myocytes. While altered Ca2+-homeostasis has been demonstrated in ...

Cardiovascular Research, Review, Burkert Pieske, Steven R Houser

Date : 15/03/2003 Item size : 469474 bytes
Ehjcardiovascrec

Methods: We studied four male patients who received hearts from female donors, and four female patients who received an allograft from a male donor. The great clinical impact of heart failure and ...

Cardiovascular Research, Original Article, Antoni Bayes-Genis, Marta Salido, Francesc Solé Ristol, Mireia Puig, Vicens Brossa, Marta Campreciós, Josep M Corominas, Mª Luı̈sa ...

Date : 01/12/2002 Item size : 241771 bytes
Ehjcardiovascrec

[...]impairments in glucose utilization and suppression of fatty acid oxidation in myocytes in the pathological state ultimately lead to a deficiency in energy supply to overloaded myocardium.2,5 ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON METABOLIC REMODELLING IN HEART FAILURE, Ying Huang, Meiyi Zhou, Haipeng Sun, Yibin Wang

Date : 01/05/2011 Item size : 259509 bytes
Ehjcardiovascrec

[...]altered expression of PLB and SLN has been reported in many cardiac diseases. [...]SERCA2a is a major regulator of intracellular Ca2+ homeostasis, and changes in the expression and activity of ...

Cardiovascular Research, Review, Muthu Periasamy, Poornima Bhupathy, Gopal J. Babu

Date : 15/01/2008 Item size : 520644 bytes
Ehjcardiovascrec

Creation of transgenic or knock-in animals expressing mutant proteins in their hearts confirmed that these mutations in genes for sarcomeric proteins induced distinct types of cardiomyopathies and ...

Cardiovascular Research, REVIEWS: FOCUS ON THE CARDIAC SARCOMERE, Sachio Morimoto

Date : 01/03/2008 Item size : 477068 bytes
Ehjcardiovascrec

Transgenic mice with cardiac-specific expression of an active form of calcineurin display depressed function, hypertrophy and heart failure. The apparent disparity in contractile properties between ...

Cardiovascular Research, Original Article, Guoxiang Chu, Andrew N. Carr, Karen B. Young, J.William Lester, Atsuko Yatani, Atsushi Sanbe, Melissa C. Colbert, Steven M. Schwartz, Konrad F. Frank, Paul ...

Date : 01/04/2002