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Methods: MI was induced by permanent ligation of the left coronary artery in male normotensive Wistar rats. At these time points, mean arterial blood pressure (MAP), heart rate (HR), left ...

Cardiovascular Research, Original Article, Steffen Sandmann, Jiang-Yong Min, Achim Meissner, Thomas Unger

Date : 01/10/1999 Item size : 409874 bytes

Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes

Abstract Objective:: Transforming growth factor (TGF)-β promotes the deposition of extracellular matrix protein and also acts as an anti-inflammatory cytokine. Methods:: Anterior MI was produced ...

Cardiovascular Research, Research Article, Masaki Ikeuchi, Hiroyuki Tsutsui, Tetsuya Shiomi, Hidenori Matsusaka, Shouji Matsushima, Jing Wen, Toru Kubota, Akira Takeshita

Date : 01/12/2004 Item size : 252606 bytes

[...]sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. [...]many researchers are trying to understand whether left ...

Cardiovascular Research, Review, Giulio Selvetella, Emilio Hirsch, Antonella Notte, Guido Tarone, Giuseppe Lembo

Date : 15/08/2004 Item size : 431911 bytes

A reduction of this gradient has been implicated in a variety of pathologies including ischaemia/reperfusion,1,2 hypertrophy, and heart failure (HF).35 In hypertrophy and HF, many aspects of ...

Cardiovascular Research, Cardiac biology and remodelling, Andrii Boguslavskyi, Davor Pavlovic, Karen Aughton, James E. Clark, Jacqueline Howie, William Fuller, Michael J. Shattock

Date : 01/10/2014 Item size : 304021 bytes

Adenovirus mediated gene transfer provides an approach to study functional consequences of SERCA2a overexpression in cardiac myocytes in vitro [1], and a transgenic mouse model allows the effects of ...

Cardiovascular Research, Review, Markus Meyer, Wolfgang H Dillmann

Date : 01/02/1998 Item size : 277106 bytes

Abstract Aims Left ventricular hypertrophy is a risk factor for heart failure. Glucose and fatty acid oxidation as well as contractile function ex vivo were assessed in the isolated working heart, ...

Cardiovascular Research, Original Article, Torsten Doenst, Gracjan Pytel, Andrea Schrepper, Paulo Amorim, Gloria Färber, Yasushige Shingu, Friedrich W. Mohr, Michael Schwarzer

Date : 01/06/2010 Item size : 346381 bytes

Methods and results Immunological and cell physiological analyses revealed that TRPV2 is highly concentrated and activated in the ventricular sarcolemma of DCM patients and three animal ...

Cardiovascular Research, Ion channels and arrhythmias, Yuko Iwata, Hitomi Ohtake, Osamu Suzuki, Junichiro Matsuda, Kazuo Komamura, Shigeo Wakabayashi

Date : 01/09/2013 Item size : 304346 bytes

The magnitude of late INa in cardiac myocytes may be increased by either acquired conditions such as heart failure,12,2326 hypoxia/ischaemia,8,2729 inflammation,30 oxidative stress,31 and thyroid ...

Cardiovascular Research, TOPICAL REVIEW, John C. Shryock, Yejia Song, Sridharan Rajamani, Charles Antzelevitch, Luiz Belardinelli

Date : 01/09/2013 Item size : 741695 bytes

KeywordsCardiomyopathyHeart failureContractile functionRemodelingVentricular functionTime for primary review 33 days. 1 Introduction Heart failure was defined by Braunwald as the pathophysiologic ...

Cardiovascular Research, Review, Stefan Hein, Sawa Kostin, Annette Heling, Yoshi Maeno, Jutta Schaper

Date : 14/01/2000 Item size : 261696 bytes