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For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Review, Elizabeth A. Woodcock, Xiao-Jun Du, Melissa E. Reichelt, Robert M. Graham

Date : 01/02/2008 Item size : 499739 bytes

KeywordsArrhythmia (mechanisms)Contractile functionHeart failureHypertrophyNa/H-exchangerNa/K-pumpTime for primary review 26 days. 1 [Na]i in hypertrophy and heart failure Myocardial hypertrophy ...

Cardiovascular Research, Review, Steven M Pogwizd, Karin R Sipido, Fons Verdonck, Donald M Bers

Date : 15/03/2003 Item size : 394084 bytes

Abstract Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only ...

Cardiovascular Research, Original Article, Pawan K Singal, Neelam Khaper, Vince Palace, Dinender Kumar

Date : 01/12/1998 Item size : 389435 bytes

Abstract Objective: The cardiac ankyrin repeat protein (CARP), a nuclear transcription co-factor that negatively regulates cardiac gene expression, is increased in human heart failure and in animal ...

Cardiovascular Research, Original Article, Oliver Zolk, Michael Marx, Elmar Jäckel, Ali El-Armouche, Thomas Eschenhagen

Date : 01/09/2003 Item size : 258892 bytes

Abstract Proper contractile function of the heart depends on intact excitationcontraction processes and ion homeostasis of the myocytes. While altered Ca2+-homeostasis has been demonstrated in ...

Cardiovascular Research, Review, Burkert Pieske, Steven R Houser

Date : 15/03/2003 Item size : 469474 bytes

[...]a decrease in ATP production in cardiomyocytes will cause a decrease in Ca2+ gradients across the sarcolemmal and sarcoplasmic membranes, together with elevated cytoplasmic Ca2+ levels, as is ...

Cardiovascular Research, Review, Desiree Abdurrachim, Joost J.F.P. Luiken, Klaas Nicolay, Jan F.C. Glatz, Jeanine J. Prompers, Miranda Nabben

Date : 01/05/2015 Item size : 553034 bytes

Abstract Aims Left ventricular hypertrophy is a risk factor for heart failure. Glucose and fatty acid oxidation as well as contractile function ex vivo were assessed in the isolated working heart, ...

Cardiovascular Research, Original Article, Torsten Doenst, Gracjan Pytel, Andrea Schrepper, Paulo Amorim, Gloria Färber, Yasushige Shingu, Friedrich W. Mohr, Michael Schwarzer

Date : 01/06/2010 Item size : 346381 bytes

The magnitude of late INa in cardiac myocytes may be increased by either acquired conditions such as heart failure,12,2326 hypoxia/ischaemia,8,2729 inflammation,30 oxidative stress,31 and thyroid ...

Cardiovascular Research, TOPICAL REVIEW, John C. Shryock, Yejia Song, Sridharan Rajamani, Charles Antzelevitch, Luiz Belardinelli

Date : 01/09/2013 Item size : 741695 bytes

KeywordsCardiomyopathyHeart failureContractile functionRemodelingVentricular functionTime for primary review 33 days. 1 Introduction Heart failure was defined by Braunwald as the pathophysiologic ...

Cardiovascular Research, Review, Stefan Hein, Sawa Kostin, Annette Heling, Yoshi Maeno, Jutta Schaper

Date : 14/01/2000 Item size : 261696 bytes

Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure. Introduction Activation ...

Cardiovascular Research, Review, Liza Barki-Harrington, Cinzia Perrino, Howard A Rockman

Date : 15/08/2004 Item size : 572672 bytes