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Ehjcardiovascrec

The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myocardial ...

Cardiovascular Research, Review, Davy Vanhoutte, Mark Schellings, Yigal Pinto, Stephane Heymans

Date : 15/02/2006 Item size : 594416 bytes
Ehjcardiovascrec

Methods: Chronic MI was induced in young adult (3.5 months) and aged (18 months) female SpragueDawley rats by ligation of the left coronary artery. Results: Aged control rats differed from young ...

Cardiovascular Research, Original Article, Alexander Deten, Grit Marx, Wilfried Briest, Hans Christian Volz, Heinz-Gerd Zimmer

Date : 01/05/2005 Item size : 291031 bytes
Ehjcardiovascrec

Several studies suggest that such modulation of MMP activity can alter ventricular remodeling, myocardial dysfunction, and the progression of heart failure. KeywordsExtracellular matrixGene ...

Cardiovascular Research, Review, Yun You Li, Charles F. McTiernan, Arthur M. Feldman

Date : 01/05/2000 Item size : 466619 bytes
Ehjcardiovascrec

miRNAs influence key physiological processes, such as proliferation, migration, differentiation, secretion, excitation, conduction, cell cycle, and apoptosis, by altering protein expression of ...

Cardiovascular Research, REVIEWS: FOCUS ON MICRORNA IN CARDIOVASCULAR BIOLOGY AND DISEASE, S. Dangwal, C. Bang, T. Thum

Date : 15/03/2012 Item size : 441676 bytes
Ehjcardiovascrec

During ventricular remodelling following sustained periods of pressure overload, cardiac fibroblasts become activated and start producing excessive amounts of ECM proteins, such as fibrillar ...

Cardiovascular Research, Cardiac biology and remodelling, Kate M. Herum, Ida G. Lunde, Biljana Skrbic, William E. Louch, Almira Hasic, Sigurd Boye, Andreas Unger, Sverre-Henning Brorson, Ivar ...

Date : 01/05/2015 Item size : 354118 bytes
Ehjcardiovascrec

Abstract Objective:: Transforming growth factor (TGF)-β promotes the deposition of extracellular matrix protein and also acts as an anti-inflammatory cytokine. Methods:: Anterior MI was produced ...

Cardiovascular Research, Research Article, Masaki Ikeuchi, Hiroyuki Tsutsui, Tetsuya Shiomi, Hidenori Matsusaka, Shouji Matsushima, Jing Wen, Toru Kubota, Akira Takeshita

Date : 01/12/2004 Item size : 252606 bytes
Ehjcardiovascrec

Both proteolytic enzymes degrade a wide variety of connective tissue components and thus the increased levels found may play an important role in the structural remodelling seen in the myocardium and ...

Cardiovascular Research, Original Article, Sophie J Gilbert, Paul R Wotton, John F Tarlton, Victor C Duance, Allen J Bailey

Date : 01/05/1997 Item size : 174741 bytes
Ehjcardiovascrec

[...]anti-fibrotic strategies are increasingly recognized as a promising approach in the prevention and treatment of heart failure. [...]dissecting the molecular mechanisms underlying the ...

Cardiovascular Research, Review, Esther E. Creemers, Yigal M. Pinto

Date : 01/02/2011 Item size : 426359 bytes
Ehjcardiovascrec

Adverse remodelling of the heart associated with hypertension, valve disease, or myocardial infarction includes diverse functional, structural, and metabolic abnormalities, such as sarcomere ...

Cardiovascular Research, EDITORIALS: SPOTLIGHT ON LANDMARK PAPERS IN, Johann Bauersachs

Date : 01/11/2012 Item size : 172663 bytes
Ehjcardiovascrec

In disease states, fibroblast production of increased quantities of ECM proteins leads to tissue fibrosis, which can impair both mechanical and electrical function of the heart, contributing to heart ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Lixia Yue, Jia Xie, Stanley Nattel

Date : 01/03/2011 Item size : 519835 bytes