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[...]although hypertension increases the risk for developing HF,1 LVH itself is an independent risk factor for HF.1,2 Furthermore, in spite of the continuous progress of antihypertensive strategies ...

Cardiovascular Research, Review, Arantxa González, Begoña López, Susana Ravassa, Javier Beaumont, Teresa Arias, Nerea Hermida, Amaia Zudaire, Javier Díez

Date : 15/02/2009 Item size : 443888 bytes

Abstract Aims High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. Conclusion These results ...

Cardiovascular Research, Cardiac biology and remodelling, Akira Funayama, Tetsuro Shishido, Shunsuke Netsu, Taro Narumi, Shinpei Kadowaki, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, ...

Date : 01/09/2013 Item size : 301103 bytes

Abstract Primary diastolic failure is typically seen in patients with hypertensive or valvular heart disease as well as in hypertrophic or restrictive cardiomyopathy but can also occur in a variety ...

Cardiovascular Research, Review, Lazar Mandinov, Franz R. Eberli, Christian Seiler, Otto M. Hess

Date : 01/03/2000 Item size : 405328 bytes

Abstract Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only ...

Cardiovascular Research, Original Article, Pawan K Singal, Neelam Khaper, Vince Palace, Dinender Kumar

Date : 01/12/1998 Item size : 389435 bytes

Cardiac cell growth in response to pressure or volume overload, as well as physiological adaptive hypertrophy, is accompanied by an increase in protein ubiquitination, proteasome subunit expression, ...

Cardiovascular Research, Review, Nadia Hedhli, Christophe Depre

Date : 15/01/2010 Item size : 449160 bytes

Despite considerable progress in the understanding and management of heart failure, its incidence, prevalence and economic burden are steadily increasing. [...]efficient preventive and therapeutic ...

Cardiovascular Research, Review, Rainer Klocke, Wen Tian, Michael T. Kuhlmann, Sigrid Nikol

Date : 01/04/2007 Item size : 378011 bytes

[...]endothelial mitochondria are centrally involved in maintaining the fine regulatory balance between mitochondrial calcium concentration, reactive oxygen species (ROS) production, and ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Sean Michael Davidson

Date : 01/10/2010 Item size : 527437 bytes

Anaplerosis refers to metabolic pathways that replenish the citric acid cycle intermediates, which are essential to energy metabolism; however, our understanding of the role and regulation of this ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON METABOLIC REMODELLING IN HEART FAILURE, Christine Des Rosiers, François Labarthe, Steven G. Lloyd, John C. Chatham

Date : 01/05/2011 Item size : 509696 bytes

Abstract Objective: Chronic heart failure is associated with a decreased responsiveness of the heart to β-adrenergic receptor agonists. Conclusion: The amount and activity of nucleoside ...

Cardiovascular Research, Original Article, Susanne Lutz, Roman Mura, Doris Baltus, Matthew Movsesian, Wolfgang Kübler, Feraydoon Niroomand

Date : 01/01/2001 Item size : 248071 bytes

The prevalence of depression among heart failure patients steeply increases with the severity of heart failure, reaching a rate of >40% in patients with New York Heart Association functional class ...

Cardiovascular Research, Editorial, Heimo Ehmke

Date : 01/01/2012 Item size : 167466 bytes