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Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes

In the isolated perfused hearts of five of these 14 mice cytosolic and mitochondrial ATP/ADP-ratios, determined by nonaqueous fractionation, were significantly altered, signalling a reduced ANT ...

Cardiovascular Research, Original Article, Karsten Schulze, Bernhard Witzenbichler, Claudia Christmann, Heinz-Peter Schultheiss

Date : 01/10/1999 Item size : 294407 bytes

Methods: MI was induced by permanent ligation of the left coronary artery in male normotensive Wistar rats. At these time points, mean arterial blood pressure (MAP), heart rate (HR), left ...

Cardiovascular Research, Original Article, Steffen Sandmann, Jiang-Yong Min, Achim Meissner, Thomas Unger

Date : 01/10/1999 Item size : 409874 bytes

Abstract Objective: Because statins promote endogenous nitric oxide (NO) production in vessels by increasing endothelial nitric oxide synthase (eNOS), we evaluated the clinical benefit and efficiency ...

Cardiovascular Research, Original Article, Jean-Noel Trochu, Seema Mital, Xiao-ping Zhang, Xiaobin Xu, Manuel Ochoa, James K Liao, Fabio A Recchia, Thomas H Hintze

Date : 01/11/2003 Item size : 293750 bytes

In the present studies, eprosartan's ability to provide end-organ protection was evaluated in a model of cardiomyopathy and renal failure in stroke-prone rats (SP). Echocardiographic (i.e. 2-D ...

Cardiovascular Research, Original Article, Frank C. Barone, Robert W. Coatney, Sudeep Chandra, Susanta K. Sarkar, Allen H. Nelson, Lisa C. Contino, David P. Brooks, Wallace G. Campbell, Eliot H. ...

Date : 01/06/2001 Item size : 322347 bytes

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients Methods and Results: We report the ...

Cardiovascular Research, Original Article, Robert J MacFadyen, Craig S Barr, Allan D Struthers

Date : 01/07/1997 Item size : 217650 bytes

Abstract Objective Many patients with heart failure have whole-body insulin resistance and reduced cardiac fluorodeoxyglucose uptake, but whether these metabolic changes have detrimental effects on ...

Cardiovascular Research, Original Article, Andrew J. Murray, Craig A. Lygate, Mark A. Cole, Carolyn A. Carr, George K. Radda, Stefan Neubauer, Kieran Clarke

Date : 01/07/2006 Item size : 331475 bytes

Abstract Objective: The purpose of this study was to examine the degree to which mechanical alterations in left ventricular papillary muscles of renal hypertensive-diabetic rat hearts correlate with ...

Cardiovascular Research, Original Article, Francis M Siri, Ashwani Malhotra, Stephen M Factor, Edmund H Sonnenblick, Frederick S Fein

Date : 01/04/1997 Item size : 228355 bytes

Abstract Objective: Peroxisome proliferator-activated receptor γ (PPARγ) activators may be beneficial in heart failure due to their metabolic and antihypertrophic effects, but these agents can ...

Cardiovascular Research, Original Article, Craig A Lygate, Karen Hulbert, Mina Monfared, Mark A Cole, Kieran Clarke, Stefan Neubauer

Date : 01/06/2003 Item size : 207333 bytes

Introduction Cardiac hypertrophy is an adaptive response to a variety of mechanical and hormonal stimuli, such as hypertension, valvular heart disease, and ischaemic events.1,2 However, sustained ...

Cardiovascular Research, Cardiac biology and remodelling, Yi Liu, Xiao-Li Jiang, Yu Liu, Ding-Sheng Jiang, Yan Zhang, Rui Zhang, Yingjie Chen, Qinglin Yang, Xiao-Dong Zhang, Guo-Chang Fan, Hongliang ...

Date : 01/01/2014