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For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Review, Elizabeth A. Woodcock, Xiao-Jun Du, Melissa E. Reichelt, Robert M. Graham

Date : 01/02/2008 Item size : 499739 bytes

Abstract Aims High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. Conclusion These results ...

Cardiovascular Research, Cardiac biology and remodelling, Akira Funayama, Tetsuro Shishido, Shunsuke Netsu, Taro Narumi, Shinpei Kadowaki, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, ...

Date : 01/09/2013 Item size : 301103 bytes

Protein kinase C: an introduction Protein kinase C (PKC) is a group of closely related serinethreonine protein kinases, further classified as (1) the classical PKCs (α, βI, βII, and γ), ...

Cardiovascular Research, Review, Suresh Selvaraj Palaniyandi, Lihan Sun, Julio Cesar Batista Ferreira, Daria Mochly-Rosen

Date : 01/05/2009 Item size : 465920 bytes

During ventricular remodelling following sustained periods of pressure overload, cardiac fibroblasts become activated and start producing excessive amounts of ECM proteins, such as fibrillar ...

Cardiovascular Research, Cardiac biology and remodelling, Kate M. Herum, Ida G. Lunde, Biljana Skrbic, William E. Louch, Almira Hasic, Sigurd Boye, Andreas Unger, Sverre-Henning Brorson, Ivar ...

Date : 01/05/2015 Item size : 354118 bytes

Introduction In the clinical setting, patients with heart failure suffer extremely high rates of mortality, with up to half dying within 4 years of diagnosis, a progression greater than that for ...

Cardiovascular Research, Original Article, Michael T. Massengill, Hassan M. Ashraf, Rajib R. Chowdhury, Stephen M. Chrzanowski, Jeena Kar, Sonisha A. Warren, Glenn A. Walter, Huadong Zeng, Byung-Ho ...

Date : 01/07/2016 Item size : 341757 bytes

In an attempt to understand the mechanisms that underlie the hypertrophic response, extensive investigation has centered on a characterization of the molecular pathways that initiate or maintain the ...

Cardiovascular Research, Review, Jeffery D Molkentin

Date : 15/08/2004 Item size : 423720 bytes

Some of them, including the interleukin (IL)-6 family of cytokines, have been implicated in cardioprotection, cardiac hypertrophy, inflammation, and heart failure via activation of the Janus kinase ...

Cardiovascular Research, Editorial, Jianjian Shi, Lei Wei

Date : 01/12/2012 Item size : 183175 bytes

Abstract Aims Cardiac fibrosis contributes to the transition from compensated ventricular hypertrophy to heart failure, which can be promoted by connective tissue growth factor (CTGF). Introduction ...

Cardiovascular Research, Original Article, Xuehui Liu, Yingli Gai, Fei Liu, Wei Gao, Youyi Zhang, Ming Xu, Zhaoping Li

Date : 01/10/2010 Item size : 306561 bytes

Introduction Cardiac remodelling after long-term pressure overload results in ventricular dysfunction and heart failure, which results in poor outcome and high mortality.1 One common characteristic ...

Cardiovascular Research, Original Article, Li Li, Dong Fan, Cheng Wang, Jin-Yu Wang, Xiao-Bing Cui, Dan Wu, Yun Zhou, Li-Ling Wu

Date : 01/07/2011 Item size : 293532 bytes

[...]anti-fibrotic strategies are increasingly recognized as a promising approach in the prevention and treatment of heart failure. [...]dissecting the molecular mechanisms underlying the ...

Cardiovascular Research, Review, Esther E. Creemers, Yigal M. Pinto

Date : 01/02/2011 Item size : 426359 bytes