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Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

Despite this clear need, there is currently no effective therapy for the prevention of reperfusion injury available, and the translation of drugs from experimental studies to clinical trials has been ...

Cardiovascular Research, Review, Victoria R. Pell, Edward T. Chouchani, Christian Frezza, Michael P. Murphy, Thomas Krieg

Date : 15/07/2016 Item size : 418848 bytes

The concept of cardiac remodelling was initially created to describe the changes in the anatomy of the left ventricle that occur following myocardial infarction.1 Today myocardial remodelling is used ...

Cardiovascular Research, Editorial, Javier Díez, Georg Ertl

Date : 15/02/2009 Item size : 201037 bytes

[...]endothelial mitochondria are centrally involved in maintaining the fine regulatory balance between mitochondrial calcium concentration, reactive oxygen species (ROS) production, and ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Sean Michael Davidson

Date : 01/10/2010 Item size : 527437 bytes

Abstract Aims Cardiac fibrosis contributes to the transition from compensated ventricular hypertrophy to heart failure, which can be promoted by connective tissue growth factor (CTGF). Introduction ...

Cardiovascular Research, Original Article, Xuehui Liu, Yingli Gai, Fei Liu, Wei Gao, Youyi Zhang, Ming Xu, Zhaoping Li

Date : 01/10/2010 Item size : 306561 bytes

Introduction Saturated free fatty acids such as palmitate induce apoptosis in cardiomyocytes, which has been implicated in cardiac dysfunction in obesity and diabetes.14 The induction of apoptosis by ...

Cardiovascular Research, Original Article, Huaqing Zhu, Yixin Yang, Yanpeng Wang, Jianmin Li, Peter W. Schiller, Tianqing Peng

Date : 01/10/2011 Item size : 335386 bytes

Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes Next, we examined the relation of reactive oxygen species (ROS) by ...

Cardiovascular Research, Original Article, Joji Nitobe, Seiji Yamaguchi, Masaki Okuyama, Naoki Nozaki, Masataka Sata, Takuya Miyamoto, Yasuchika Takeishi, Isao Kubota, Hitonobu Tomoike

Date : 01/01/2003 Item size : 296560 bytes

Nishijima et al.1 recently published an article in Cardiovascular Research in which they described the effects of a treatment with the nitric oxide synthase (NOS) cofactor tetrahydrobiopterin (BH4) ...

Cardiovascular Research, Letter to the Editor, Harry J. Crijns, Ulrich Schotten, An L. Moens

Date : 01/08/2011 Item size : 135921 bytes

Abstract Markers of increased oxidative stress are known to be elevated following acute myocardial infarction and in the context of chronic left ventricular hypertrophy or heart failure, and their ...

Cardiovascular Research, Review, Colin E. Murdoch, Min Zhang, Alison C. Cave, Ajay M. Shah

Date : 15/07/2006

Na+–Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury Abstract Objective: In heart failure (HF), the generation of reactive oxygen species (ROS) is ...

Cardiovascular Research, Original Article, Stefan Wagner, Tim Seidler, Eckard Picht, Lars S Maier, Victor Kazanski, Nils Teucher, Wolfgang Schillinger, Burkert Pieske, Gerrit Isenberg, Gerd ...

Date : 01/11/2003