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Abstract Aims High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. Conclusion These results ...

Cardiovascular Research, Cardiac biology and remodelling, Akira Funayama, Tetsuro Shishido, Shunsuke Netsu, Taro Narumi, Shinpei Kadowaki, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, ...

Date : 01/09/2013 Item size : 301103 bytes

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

In an attempt to understand the mechanisms that underlie the hypertrophic response, extensive investigation has centered on a characterization of the molecular pathways that initiate or maintain the ...

Cardiovascular Research, Review, Jeffery D Molkentin

Date : 15/08/2004 Item size : 423720 bytes

[...]pathological hypertrophy serves as an independent risk factor for serious cardiovascular diseases such as heart failure. With a view to developing therapeutics for this condition, molecular ...

Cardiovascular Research, INVITED EDITORIALS, Yuichi Ikeda, Eiki Takimoto, Issei Komuro

Date : 15/07/2015 Item size : 174100 bytes

[...]sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. [...]many researchers are trying to understand whether left ...

Cardiovascular Research, Review, Giulio Selvetella, Emilio Hirsch, Antonella Notte, Guido Tarone, Giuseppe Lembo

Date : 15/08/2004 Item size : 431911 bytes

[...]release of enzymes into the extracellular space was seen as important only for specialised functions, such as digestion of nutrients or in blood clotting, events that took place outside solid ...

Cardiovascular Research, Editorial, Andrew C. Newby, Matthias Pauschinger, Francis G. Spinale

Date : 15/02/2006 Item size : 167499 bytes

[...]in the mouse model, histological determination of myocyte diameter, heart weight/body weight ratio, and echocardiographic measurements revealed that myocardial expression of DYRK1A failed to ...

Cardiovascular Research, Original Article, Cornelia Grebe, Theda-Maria Klingebiel, Simon Philipp Grau, Karl Toischer, Michael Didié, Claudius Jacobshagen, Christian Dullin, Gerd Hasenfuss, Tim ...

Date : 01/06/2011 Item size : 265108 bytes

Importantly, neither the β-AR density nor the PP-1c protein levels differed from wild-type littermates, indicating no obvious major compensatory changes in the I-1 KO hearts.46,78 Moreover, ...

Cardiovascular Research, Review, Katrin Wittköpper, Dobromir Dobrev, Thomas Eschenhagen, Ali El-Armouche

Date : 01/08/2011 Item size : 468593 bytes

Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure. Introduction Activation ...

Cardiovascular Research, Review, Liza Barki-Harrington, Cinzia Perrino, Howard A Rockman

Date : 15/08/2004 Item size : 572672 bytes

In the present study, we assessed the hypothesis that cardiotoxic effects of proinflammatory cytokines are mediated by the activation of NF-κB. Methods: Transgenic mice with cardiac-specific ...

Cardiovascular Research, Original Article, Natsumi Kawamura, Toru Kubota, Shunichi Kawano, Yoshiya Monden, Arthur M. Feldman, Hiroyuki Tsutsui, Akira Takeshita, Kenji Sunagawa

Date : 01/06/2005