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Methods and results Rat isolated hearts were subjected to reversible left coronary artery occlusion (ischaemia-reperfusion) and infarct size was assessed by the tetrazolium staining ...

Cardiovascular Research, Cardiac biology and remodelling, Justin S. Bice, Yvonne Keim, Johannes-Peter Stasch, Gary F. Baxter

Date : 01/02/2014 Item size : 282285 bytes

Bortezomib 0.0875 mg/kg, pre- or post-LAD ligation Dog In vivo myocardial infarction Ischaemic loss of GRK2 and ventricular tachyarrhythmias are prevented Yu et al.,65 Huang et al.66 Epoxomicin 2.5 ...

Cardiovascular Research, Review, Xichun Yu, David C. Kem

Date : 15/01/2010 Item size : 405741 bytes

Gradually over the last 12 years dogs and cats, the classical experimental animals in cardiovascular sciences, became unfashionable for a variety of reasons, some of them nonscientific (i.e., new ...

Cardiovascular Research, Leading Article, Wolfgang Schaper, Bernd Winkler

Date : 01/07/1998 Item size : 155344 bytes

Methods Anterior MI was created in male heterozygous p53-deficient (p53+/ n=28) mice and sibling wild-type (p53+/+; n=29) mice by ligating the left coronary artery. Notably, p53+/ mice had a ...

Cardiovascular Research, Original Article, Hidenori Matsusaka, Tomomi Ide, Shouji Matsushima, Masaki Ikeuchi, Toru Kubota, Kenji Sunagawa, Shintaro Kinugawa, Hiroyuki Tsutsui

Date : 01/06/2006 Item size : 265690 bytes

The mechanisms proposed to contribute include oxygen free radical formation, calcium overload, neutrophil-mediated myocardial and endothelial injury, progressive decline in microvascular flow to the ...

Cardiovascular Research, Review, Qing-Dong Wang, John Pernow, Per-Ove Sjöquist, Lars Rydén

Date : 01/07/2002 Item size : 599139 bytes

[...]mechanisms independent of the NOS pathway have been suggested to contribute to NO synthesis during ischemia. NO initiates detrimental as well as protective mechanisms in a ...

Cardiovascular Research, Original Article, Claus Martin, Rainer Schulz, Heiner Post, Kerstin Boengler, Malte Kelm, Petra Kleinbongard, Petra Gres, Andreas Skyschally, Ina Konietzka, Gerd Heusch

Date : 01/04/2007 Item size : 303478 bytes

Introduction Patients with diabetes mellitus (DM) have an increased risk of coronary heart disease, and cardiovascular complications are responsible for the majority of diabetes-related deaths.1 In ...

Cardiovascular Research, ORIGINAL ARTICLES: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, Tao Rui, Jinchao Zhang, Xuemei Xu, Yongwei Yao, Raymond Kao, Claudio M. Martin

Date : 01/05/2012 Item size : 272777 bytes

Abstract Aims Our aim was to test the hypothesis that angiotensin II receptor blockade combined with exercise training after myocardial infarction (MI) could attenuate post-MI left ventricular ...

Cardiovascular Research, Original Article, Xiaohua Xu, Wenhan Wan, Lisa Ji, Shunhua Lao, Anthony S. Powers, Weiyan Zhao, John M. Erikson, John Q. Zhang

Date : 01/06/2008 Item size : 367993 bytes

Methods Intracellular Na+ concentration ([Na+]i) measured using 23Na-magnetic resonance spectroscopy, Na+/K+-ATPase activity, detachment of Na+/K+-ATPase α subunits from the membrane cytoskeleton, ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Victor Hernando, Ignasi Barba, Jordi Soler-Soler

Date : 01/05/2006 Item size : 287033 bytes

The purpose of this review is to provide an overview of the various strategies that inhibit RI and to discuss potential mechanisms that may contribute to the discrepancy between the promising ...

Cardiovascular Research, Review, Maurits T. Dirksen, Gerrit J. Laarman, Maarten L. Simoons, Dirk J.G.M. Duncker

Date : 01/06/2007 Item size : 612424 bytes