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Dephosphorylated PLN inhibits the SR Ca2+ pump, whereas phosphorylation of PLN, at either Ser16 by PKA or Thr17 by calmodulin-dependent protein kinase II (CaMKII), reverses this inhibition, thus ...

Cardiovascular Research, Review, Alicia Mattiazzi, Cecilia Mundiña-Weilenmann, Chu Guoxiang, Leticia Vittone, Evangelia Kranias

Date : 01/12/2005 Item size : 413808 bytes

Methods and results Repeated Ca2+ sparks were induced from individual clusters of ryanodine receptors (RyRs) in quiescent rat ventricular myocytes, and we examined how changes in RyR gating ...

Cardiovascular Research, Original Article, Hena R. Ramay, Ona Z. Liu, Eric A. Sobie

Date : 01/09/2011 Item size : 285833 bytes

There are increasing data indicating that NO modulates various proteins involved in excitationcontraction coupling (ECC), and here we discuss the evidence that NO may modulate the function of the ...

Cardiovascular Research, Review, Gregory Lim, Luigi Venetucci, David A. Eisner, Barbara Casadei

Date : 15/01/2008 Item size : 401558 bytes

Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may ...

Cardiovascular Research, Review, Nian Liu, Silvia G. Priori

Date : 15/01/2008 Item size : 341044 bytes

Methods Using simulations in a model of the guinea pig ventricular myocyte, we investigate the mutation's effect on SR Ca2+ storage, the Ca2+ transient (CaT), and its indirect effect on ionic ...

Cardiovascular Research, Original Article, Gregory M. Faber, Yoram Rudy

Date : 01/07/2007 Item size : 256495 bytes

The purpose of the present study was to determine whether gender influences the acute electrophysiological actions of genistein at the level of isolated cardiac myocytes and to elucidate the ...

Cardiovascular Research, Original Article, Reginald Liew, Mark A Stagg, Joachim Chan, Peter Collins, Kenneth T MacLeod

Date : 01/01/2004 Item size : 280335 bytes

Evidence is now emerging that hyperphosphorylation of the cardiac ryanodine receptor is an important event in chronic heart failure, contributing to impaired contraction and the generation of ...

Cardiovascular Research, Review, Mark Scoote, Alan J Williams

Date : 01/12/2002 Item size : 402108 bytes

Virtually every cellular action triggered by electrical activitye.g., muscle contraction, neurotransmitter release, or hormone secretiondepends upon an increase in the concentration of intracellular ...

Cardiovascular Research, Review in Review Focus Series on Calmodulin and Ca, Geoffrey S. Pitt

Date : 01/03/2007 Item size : 333074 bytes

Abstract Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in a rabbit model ...

Cardiovascular Research, Original Article, Susan Currie, Godfrey L. Smith

Date : 01/01/1999 Item size : 286941 bytes

Together with the intriguing feature that the cholesterol content of plasma membranes is considerably higher than that of subcellular membranes, there is ample evidence for a significant role of ...

Cardiovascular Research, Review, E.M.Lars Bastiaanse, Karin M Höld, Arnoud Van der Laarse

Date : 01/02/1997 Item size : 233863 bytes