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Clinically, chronic systolic LV overload most commonly results from myocardial infarction (MI), or chronic pressure overload, including hypertension and aortic stenosis.1 Despite the apparent ...

Cardiovascular Research, Editorial, Dirk J. Duncker, Elza D. van Deel

Date : 01/03/2012 Item size : 179893 bytes

Low ATP content in cardiac tissue was observed in patients with chronic heart failure despite the absence of myocardial ischaemia [1]. Mitochondrial function in cardiac tissue from the failing heart ...

Cardiovascular Research, Editorial, William C Stanley, Charles L Hoppel

Date : 01/03/2000 Item size : 172386 bytes

Recap on NOS distribution and function in cardiovascular tissues Nitric oxide (NO) is a key universal signalling molecule in the cardiovascular system, acting on both acute and more chronic ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, Boris Manoury, Virginie Montiel, Jean-Luc Balligand

Date : 01/05/2012 Item size : 553690 bytes

Studies have revealed substantial ultrastructural alterations in several parts of the cardiomyocytes during cardiac disease, including the sarcoplasmic reticulum (SR)2 and transverse (T)-tubules,3,4 ...

Cardiovascular Research, Editorial, Fredrik Swift, Geir Christensen

Date : 01/09/2012 Item size : 179116 bytes

[...]SR and mitochondria interact physiologically to control cellular Ca2+ homeostasis. Alterations in the function of the SR are now known to be of primary importance for the development of ...

Cardiovascular Research, Editorial, David Garcia-Dorado, Hans Michael Piper, David A. Eisner

Date : 15/01/2008 Item size : 191287 bytes

Abstract Objective: We recently reported that doxorubicin (Dox), an effective anti-cancer drug, induces apoptosis in cardiac myocytes in association with reduction of Bcl-xl ...

Cardiovascular Research, Original Article, Keita Kunisada, Eiroh Tone, Shinji Negoro, Yoshikazu Nakaoka, Yuichi Oshima, Tomoaki Osugi, Masanobu Funamoto, Masahiro Izumi, Yasushi Fujio, Hisao Hirota, ...

Date : 01/03/2002 Item size : 258629 bytes

Prolonged myocardial ischemia leads to the loss of viable tissue in the heart, even if the ischemic episode is eventually ended by reperfusion. According to this hypothesis, it is an uncontrolled ...

Cardiovascular Research, Viewpoint Editorial, Hans Michael Piper, Sascha Kasseckert, Yaser Abdallah

Date : 01/05/2006 Item size : 183068 bytes

Genetically caused dilated cardiomyopathy (DCM) is typically diagnosed between 40 and 60 years and patients often present with heart failure or advanced arrhythmia, which may possibly lead to stroke ...

Cardiovascular Research, INVITED EDITORIALS, Michael Wagner, Silvio Weber, Ali El-Armouche

Date : 01/07/2015 Item size : 160968 bytes

[...]Sp mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. Previously, studies have found that protein ...

Cardiovascular Research, Ion channels and arrhythmias, David Y. Chiang, Na Li, Qiongling Wang, Katherina M. Alsina, Ann P. Quick, Julia O. Reynolds, Guoliang Wang, Darlene Skapura, Niels Voigt, ...

Date : 01/07/2014 Item size : 333015 bytes

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Niels Voigt, Xander H.T. Wehrens

Date : 01/03/2011 Item size : 506157 bytes