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SWAP mice carry two amino acid mutations in NKA-αisoforms so that NKA-α1 is ouabain sensitive and NKA-α2 is ouabain resistant.14 The mutations do not affect the haemodynamic parameters and ...

Cardiovascular Research, Original Article, Sanda Despa, Jerry B. Lingrel, Donald M. Bers

Date : 01/09/2012 Item size : 271019 bytes

Abstract Objective: A decrease in plasma T3 concentration is a frequent finding in patients with heart failure. Results: When stimulated with cyclopiazonic acid, a SERCA-2 inhibitor, T3-deprived ...

Cardiovascular Research, Original Article, Francesca Forini, Aldo Paolicchi, Tommaso Pizzorusso, Gian Michele Ratto, Michela Saviozzi, Vittorio Vanini, Giorgio Iervasi

Date : 01/08/2001 Item size : 256376 bytes

KeywordsArrhythmia (mechanisms)Contractile functionHeart failureNa/Ca-exchangerSarcolemmaTime for primary review 21 days. 1 Introduction Sarcolemmal Na+Ca2+ exchange plays a pivotal role in ion ...

Cardiovascular Research, Review, Wolfgang Schillinger, Jan W Fiolet, Klaus Schlotthauer, Gerd Hasenfuss

Date : 15/03/2003 Item size : 515169 bytes

Introduction In patients with ST-segment elevation acute myocardial infarction (AMI), the main therapeutic goal is to restore coronary flow as soon as possible by means of percutaneous intervention ...

Cardiovascular Research, Review, Javier Inserte, José A. Barrabés, Víctor Hernando, David Garcia-Dorado

Date : 15/07/2009 Item size : 489326 bytes

Keywordsβ2-adrenergic agonistHypertrophyRat, ventricleTime for primary review 31 days. 1 Introduction Previous studies have shown that different stimuli induce cardiac hypertrophy in animals with ...

Cardiovascular Research, Original Article, Kit Wong, Kenneth R Boheler, Jill Bishop, Mario Petrou, Magdi H Yacoub

Date : 01/01/1998 Item size : 264423 bytes

[...]altered expression of PLB and SLN has been reported in many cardiac diseases. [...]SERCA2a is a major regulator of intracellular Ca2+ homeostasis, and changes in the expression and activity of ...

Cardiovascular Research, Review, Muthu Periasamy, Poornima Bhupathy, Gopal J. Babu

Date : 15/01/2008 Item size : 520644 bytes

Nonetheless, cardiac remodelling seems to develop in response to increased haemodynamic overload, increased workload, increased ventricular wall tension as well as elevated levels of different ...

Cardiovascular Research, Review, Naranjan S. Dhalla, Harjot K. Saini-Chohan, Delfin Rodriguez-Leyva, Vijayan Elimban, Melissa R. Dent, Paramjit S. Tappia

Date : 15/02/2009 Item size : 566412 bytes

[...]deregulated calpain activity has been associated with a variety of pathophysiological conditions which have in common the loss of intracellular Ca2+ control.1 A large amount of experimental data ...

Cardiovascular Research, REVIEWS: FOCUS ON THE CALPAIN FAMILY IN THE CARDIOVASCULAR SYSTEM, Javier Inserte, Victor Hernando, David Garcia-Dorado

Date : 01/10/2012 Item size : 559929 bytes

Three studies, one from the lab of Timothy Regan [1], another from James Scheuer's group [2]and the third from Edmund Sonnenblick's lab [3], were critical in providing comprehensive descriptions of ...

Cardiovascular Research, Review, Grant N Pierce, James C Russell

Date : 01/04/1997 Item size : 192151 bytes

Results: The results showed striking changes in the mass distribution of calsequestrin molecules present in tissue from heart failure (five animals) compared with control (five ...

Cardiovascular Research, Original Article, Arash Kiarash, Carmen E Kelly, Brett S Phinney, Héctor H Valdivia, Judith Abrams, Steven E Cala

Date : 01/08/2004