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Methods: Open chest dogs undergoing 15 min of left anterior descending coronary artery occlusion and 3 h of reperfusion were randomized to intracoronary infusions of 0.9% saline, vehicle, or the Ca2+ ...

Cardiovascular Research, Original Article, Steven C Smart, Kiran B Sagar, Jo El Schultz, David C Warltier, Larry R Jones

Date : 01/11/1997 Item size : 332368 bytes

Abstract Objectives: This study aims at clarifying the role of cellular Ca2+ overload and spontaneous sarcoplasmic reticulum (SR) Ca2+ release in the generation of early afterdepolarizations (EAD) by ...

Cardiovascular Research, Original Article, Paul G.A Volders, Attila Kulcsár, Marc A Vos, Karin R Sipido, Hein J.J Wellens, Ralph Lazzara, Bela Szabo

Date : 01/05/1997 Item size : 219807 bytes

Three factors combine to the enhanced propensity for the occurrence of delayed afterdepolarizations: (1) increased activity of the Na/Ca exchanger, (2) a reduced inward rectifier, (3) residual ...

Cardiovascular Research, Review, Michiel J Janse

Date : 01/02/2004 Item size : 449802 bytes

Conclusion: Data show that SR Ca2+ release and SR Ca2+ content were increased in hypertrophied myocytes, despite an increase in the steady state INa/Ca density. The observation that increased SR ...

Cardiovascular Research, Original Article, Alzbeta Chorvatova, George Hart, Munir Hussain

Date : 01/02/2004 Item size : 266773 bytes

Methods: Rat mesenteric small arteries (RMSA) were mounted on a pressure myograph and the functional (lumen diameter and Ca2+ oscillations) and ultrastructural effects of the phosphatase inhibitor ...

Cardiovascular Research, Original Article in Review Focus Series on Caveolae in Cardiovascular Signaling, Linda Shaw, Michele A. Sweeney, Stephen C. O'Neill, Carolyn J.P. Jones, Clare Austin, Michael ...

Date : 01/03/2006 Item size : 281926 bytes

Time for primary review 26 days. 1 The Na,K-ATPase The Na,K-ATPase (sodium, potassium adenosine triphosphatase) or the Na,K-pump is an ubiquitous enzyme which performs the active transport of Na and ...

Cardiovascular Research, Review, Thomas A Schmidt, Keld Kjeldsen

Date : 01/02/1998 Item size : 475442 bytes

Abstract Objective: Ca2+ release from the cardiac junctional sarcoplasmic reticulum (SR) is regulated by a complex of proteins, including the ryanodine receptor (RyR), calsequestrin (CSQ), junctin ...

Cardiovascular Research, Original Article, Uwe Kirchhefer, Larry R Jones, Frank Begrow, Peter Boknik, Lutz Hein, Martin J Lohse, Burkhard Riemann, Wilhelm Schmitz, Jörg Stypmann, Joachim Neumann

Date : 01/04/2004 Item size : 335090 bytes

[...]the effect of the rise in cytosolic calcium is amplified by enhanced calcium sensitivity of the actin/myosin interaction, achieved by the hypoxia-induced increase in Rho-kinase activity. Ion ...

Cardiovascular Research, Review in Review Focus Series on Hypoxia and the Pulmonary Circulation, E. Kenneth Weir, Andrea Olschewski

Date : 01/09/2006 Item size : 510430 bytes

The following criteria were considered when reviewing the literature: (i) the type of smooth muscle, i.e. either tonic or phasic, (ii) the source of the smooth muscle i.e. pulmonary, systemic, large ...

Cardiovascular Research, Review, G.L. Smith, C. Austin, C. Crichton, S. Wray

Date : 01/05/1998 Item size : 510471 bytes

Introduction A growing body of evidence in the literature suggests that abnormal channel gating of the sarcoplasmic reticulum (SR) Ca2+ release channel, the cardiac ryanodine receptor (RyR2), is one ...

Cardiovascular Research, Original Article, Makoto Ono, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, ...

Date : 01/09/2010 Item size : 255843 bytes